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Article
Open AccessGenetic etiology and pregnancy outcomes of fetuses with central nervous system anomalies
To investigate genetic etiology and pregnancy outcomes of fetal central nervous system (CNS) anomalies.
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Article
Open AccessmTORC1 accelerates osteosarcoma progression via m6A-dependent stabilization of USP7 mRNA
Osteosarcoma (OS) is considered a sex steroid hormone-dependent bone tumor. The development and progression of OS are regulated by 17β-estradiol (E2). However, the detailed mechanisms of E2-modulated OS progre...
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Article
Open AccessHaploinsufficiencies of FOXF1, FOXC2 and FOXL1 genes originated from deleted 16q24.1q24.2 fragment related with alveolar capillary dysplasia with misalignment of pulmonary veins and lymphedema-distichiasis syndrome: relationship to phenotype
We describe a fetus with a 2.12-Mb terminal deleted fragment in 16q associated with alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) and lymphedema-distichiasis syndrome (LDS) and int...
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Article
The nuclear transportation of PD-L1 and the function in tumor immunity and progression
As the main immune checkpoint, PD-L1-PD-1 interaction plays a critical role in the dysregulation of effector T cells, which contributes to the failure of Chimeric Antigen Receptor T-cell (CAR-T) and other immu...
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Article
Open AccessSpatiotemporal regulation of angiogenesis/osteogenesis emulating natural bone healing cascade for vascularized bone formation
Engineering approaches for growth factor delivery have been considerably advanced for tissue regeneration, yet most of them fail to provide a complex combination of signals emulating a natural healing cascade,...
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Article
Open AccessEstrogen/ER in anti-tumor immunity regulation to tumor cell and tumor microenvironment
As the essential sexual hormone, estrogen and its receptor has been proved to participate in the regulation of autoimmunity diseases and anti-tumor immunity. The adjustment of tumor immunity is related to the ...
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Article
Plantations modified leaf elemental stoichiometry compared to the native shrub community in karst areas, Southwest of China
Nutrient limitation changed from N–P co-limitation in the native shrubs to N limitation in the plantations.
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Article
Microstructure Evolution and Corrosion Behavior of Deformed Austenitic Stainless Steel Manufactured by Selective Laser Melting
The effect of room temperature deformation on the microstructure and corrosion behavior of selective laser-melted (SLM) 316L steel in 0.9 wt.% NaCl medium was explored by electrochemical tests, microstructural...
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Article
Abnormal Evolution of Pitting Behavior of Warmly Pre-Strained Austenitic Stainless Steels
The effect of warm pre-strain on the corrosion behavior of 304 and 316 steels in 3.5% NaCl solution was first explored by electrochemical tests, passive film characterization, and structural analysis. The pitt...
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Article
Influence of Warm Predeformation Temperature on the Corrosion Property of Type 304 Austenitic Stainless Steel
The influence of predeformation temperature (100-400 °C) on the corrosion property of the predeformed 304 austenitic stainless steel (SS) in 3.5 wt.% NaCl medium was studied by electrochemical and microstructu...
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Article
Open AccessEstrogen receptor β induces autophagy of osteosarcoma through the mTOR signaling pathway
Estrogen receptor beta (ERβ) was considered as a tumor-inhibiting factor in estrogen-sensitive malignant tumors. In this study, we intended to investigate whether ERβ was involved in inducing autophagy in oste...
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Chapter
B-Cells in Cancer Immunology: For or Against Cancer Growth?
The role played by B-cells in cancer immunology is complex and somewhat controversial. Depending upon their state of activation, B-cells have had divergent roles in T-cell differentiation and effector function...
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Article
Open AccesslncRNAs: function and mechanism in cartilage development, degeneration, and regeneration
With the increasing incidence of cartilage-related diseases such as osteoarthritis (OA) and intervertebral disc degeneration (IDD), heavier financial and social burdens need to be faced. Unfortunately, there i...
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Article
Open AccessCheckpoint kinase inhibitor AZD7762 enhance cisplatin-induced apoptosis in osteosarcoma cells
AZD7762 is a checkpoint kinase 1 (Chk 1) inhibitor, which has been reported to sensitize many tumor cells to DNA damage. However, whether AZD7762 could sensitize osteosarcoma cells to chemotherapy cisplatin ha...
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Article
Open AccessAnti-CD166/4-1BB chimeric antigen receptor T cell therapy for the treatment of osteosarcoma
Chimeric antigen receptor (CAR)-engineered T cells have displayed outstanding performance in the treatment of patients with hematological malignancies. However, their efficacy against solid tumors has been lar...
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Article
Chlorogenic acid attenuates virulence factors and pathogenicity of Pseudomonas aeruginosa by regulating quorum sensing
Quorum sensing (QS) is a cell-to-cell communication that is used by bacteria to regulate collective behaviors. Quorum sensing controls virulence factor production in many bacterial species and it is regarded a...
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Article
Hydrogen Effect on the Fatigue Crack Growth in Austenitic Stainless Steel Investigated by a New Method Based on Nanohardness Distribution
A new method of nanohardness distribution for investigating the hydrogen effect on the fatigue crack in austenitic stainless steels was developed. The nanohardness distribution around the fatigue crack tip is ...
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Article
Imbalanced plant stoichiometry at contrasting geologic-derived phosphorus sites in subtropics: the role of microelements and plant functional group
Subtropical soils are generally characterized as deficient in phosphorus (P), calcium (Ca) and magnesium (Mg), but rich in iron (Fe) and aluminum (Al). However, soils developed in phosphate rock are extremely ...
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Article
Open AccessEffectiveness of transcutaneous electrical nerve stimulation for the treatment of migraine: a meta-analysis of randomized controlled trials
Migraine is now ranked as the second most disabling disorder worldwide reported by the Global Burden of Disease Study 2016. As a noninvasive neurostimulation technique, transcutaneous electrical nerve stimulat...
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Article
Open AccessEscin induces caspase-dependent apoptosis and autophagy through the ROS/p38 MAPK signalling pathway in human osteosarcoma cells in vitro and in vivo
Osteosarcoma is one of the most malignant neoplasms in adolescents, and it generally develops multidrug resistance. Escin, a natural mixture of triterpene saponins isolated from Aesculus hippocastanum (horse c...
