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  1. Article

    Open Access

    In vivo deuterium magnetic resonance imaging of xenografted tumors following systemic administration of deuterated water

    In vivo deuterated water (2H2O) labeling leads to deuterium (2H) incorporation into biomolecules of proliferating cells and provides the basis for its use in cell kinetics research. We hypothesized that rapidly p...

    Jeffrey R. Brender, Julian C. Assmann, Don E. Farthing, Keita Saito in Scientific Reports (2023)

  2. Article

    Open Access

    Comparing DNA enrichment of proliferating cells following administration of different stable isotopes of heavy water

    Deuterated water (2H2O) is a label commonly used for safe quantitative measurement of deuterium enrichment into DNA of proliferating cells. More recently, it has been used for labeling proteins and other biomolec...

    Don E. Farthing, Nataliya P. Buxbaum, Philip J. Lucas in Scientific Reports (2017)

  3. No Access

    Article

    No T-cell tyrosine protein kinase signalling or calcium mobilization after CD4 association with HIV-1 or HIV-1 gp120

    THE T lymphocyte surface protein CD4 is an integral membrane glycoprotein noncovalently associated with the tyrosine protein kinase p56lck (reviewed in ref. 1). In normal T cells, surface association of CD4 molec...

    Ivan D. Horak, Mikulas Popovic, Eva M. Horak, Philip J. Lucas, Ronald E. Gress in Nature (1990)

  4. No Access

    Article

    Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones

    Cell–cell adhesion is essential for many immunological functions1–4, including interaction of cytotoxic T lymphocytes (CTLs) with their targets5–8. We have explored CTL-target interactions using well-characterize...

    Stephen Shaw, Gale E. Ginther Luce, Ralph Quinones, Ronald E. Gress in Nature (1986)