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Article
Open AccessDeletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness
The Ste20-like kinase, SLK, plays an important role in cell proliferation and cytoskeletal remodeling. In fibroblasts, SLK has been shown to respond to FAK/Src signaling and regulate focal adhesion turnover th...
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Chapter
Electrifying London: Connecting with Mainstream Markets
London’s Mayor Johnson has given a high priority to Electric Vehicles (EVs) as the most appropriate road transport technology to reduce CO2 emissions and improve air quality. This chapter outlines the policy rati...
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Article
Open AccessAntimicrobial resistance and characterisation of staphylococci isolated from healthy Labrador retrievers in the United Kingdom
Coagulase-positive (CoPS) and coagulase-negative (CoNS) staphylococci are normal commensals of the skin and mucosa, but are also opportunist pathogens. Meticillin-resistant (MR) and multidrug-resistant (MDR) i...
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Article
Open AccessUltrastructural localization of extracellular matrix proteins of the lymph node cortex: evidence supporting the reticular network as a pathway for lymphocyte migration
The lymph node (LN) is a crossroads of blood and lymphatic vessels allowing circulating lymphocytes to efficiently recognize foreign molecules displayed on antigen presenting cells. Increasing evidence indicat...
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Article
Open AccessIdentification of genes that regulate multiple cellular processes/responses in the context of lipotoxicity to hepatoma cells
In order to devise efficient treatments for complex, multi-factorial diseases, it is important to identify the genes which regulate multiple cellular processes. Exposure to elevated levels of free fatty acids ...
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Chapter and Conference Paper
Investigation of an Adaptive Cribbage Player
Cribbage is (normally) a two-player card game where the aim is to score 121 points before your opponent. The game has four stages, one of which involves discarding two cards from the six cards you are dealt. A...
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Chapter
Proadhesive Cytokine Immobilized on Endothelial Proteoglycan
Inflammation and normal immune responses depend on the recruitment of specific leukocyte populations. Similarly, the maturation of lymphocytes requires their trafficking from blood into the appropriate lymphoi...
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Article
Molecular analysis of an HLA-DP mutant cell line selected for its resistance to killing by HLA-DPw2-specific T-cell clones
A collection of HLA-DP mutants was generated, using ICR 191 as the mutagenic agent and resistance to lysis mediated by HLA-DPw2 allospecific cytotoxic T lymphocytes (CTLs) as the selection criterion. These mut...
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Article
Mucins in the mainstream
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Article
Specificity effects of run versus cycle training on ventilatory threshold
This study compared the effects of 9 weeks of run (RT) versus cycle (CT) training on ventilatory threshold (Thv) determined during treadmill (TM) and cycle ergometer (CE) graded exercise testing. Sixteen college ...
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Article
T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβ
LYMPHOCYTE migration from blood into tissue depends on integrin-mediated adhesion to endothelium1–4. Adhesion requires not only integrin ligands on the endothelium, but also activation signals because T-ce...
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Chapter
Regulation of T Cell Adhesion with T Cell Differentiation and with Acute Activation by Mip-lβ Cytokine Immobilized on CD44 Proteoglycan
Adhesion is essential to amny aspects of the T cell phsiology. Although initially it seemed plausible that this would be mediated by only a few molecules, it is now apparent that there are many adhesion molecu...
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Chapter
T Cell Adhesion Cascades: General Considerations and Illustration with CD31
Widespread appreciation of the importance of T cell adhesion has emerged only in the last 5-10 years. But now the topic is being widely discussed and many aspects carefully reviewed.1-8 This review briefly outlin...
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Article
Activation-independent binding of human memory T cells to adhesion molecule ELAM-1
THE induction of an ensemble of adhesion molecules on endothelial cells by inflammatory cytokines is likely to be crucial to the differential migration of T-lymphocyte subsets into inflammatory sites. Two mole...
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Article
Regulated expression and binding of three VLA (β1) integrin receptors on T cells
REGULATED adhesion of T cells to extracellular matrix (ECM) proteins is likely to be essential in T cell migration. Constitutive binding of various other cell types to ECM components is mediated by members of ...
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Chapter and Conference Paper
Antigen-Independent Adhesion: A Critical Process in Human Cytotoxic T Cell Recognition
Unlike solid organs, in which cell-cell contacts are largely established during morphogenesis, cells of the immune system are mobile and their contacts with other cells are transient ones. The ability to estab...
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Article
Not all in a name
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Chapter
Coordinate-Enhanced Expression of Three Adhesion Molecules (LFA-3, CD2, and LFA-1) and Three Other Molecules (4B4, UCHL1, and Pgp-1) Defines a Human T Cell Subset Containing Memory Cells and Characterized by Enhanced γ Interferon Production
Abstract: The present report summarizes our experimental findings regarding phenotypic and functional differences between two reciprocal subsets of human peripheral blood T cells: memory cells versus naive cel...
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Article
ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells
Cell-cell adhesion is essential for many immunological functions1–4. The LFA-1 molecule, a member of a superfamily of adhesion molecules, participates in adhesion which is critical to the function of each of the ...
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Article
The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3
CD2 (known also as T11 (ref. 1), LFA-2 (ref. 2) and the erythrocyte rosette receptor (ref. 3)) is a functionally important T lymphocyte surface glycoprotein of relative molecular mass 50,000 to 58,0004 (Mr 50–58...
