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Article
Sjögren syndrome
Sjögren syndrome (SjS) is a systemic autoimmune disease that primarily affects the exocrine glands (mainly the salivary and lacrimal glands) and results in the severe dryness of mucosal surfaces, principally i...
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Article
Open AccessThe neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumab
The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore ...
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Chapter
Histopathology and Glandular Biopsies in Sjögren’s Syndrome
The glandular inflammatory lesion in Sjögren’s syndrome (SS) is a distinctive but not pathognomonic chronic lymphocytic adenitis best characterized in salivary glands. The glands are readily accessible; decrea...
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Etiology and Pathogenesis of Sjögren’s Syndrome with Special Emphasis on the Salivary Glands
Pathogenesis from the Greek pathos, “disease,” and genesis, “creation,” is the process by which an etiological factor and subsequent downstream events cause disease. Although in Sjögren’s syndrome (SS), alike ...
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Chapter
Oral and Dental Manifestations of Sjögren’s Syndrome: Current Approaches to Diagnostics and Therapy
Saliva plays a detrimental role in oral health and disease. The quality and the quantity of saliva are determined by the glands it is secreted from, the sampling method, and whether secretion is stimulated or ...
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Article
Animal Models of Sjögren’s Syndrome
Sjögren’s syndrome is an autoimmune, chronic inflammatory disease characterized by focal mononuclear cell infiltration of exocrine tissues, accompanied by loss of secretory function. The pathogenesis of autoim...
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Article
Association Between Circulating Levels of the Novel TNF Family Members APRIL and BAFF and Lymphoid Organization in Primary Sjögren’s Syndrome
B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) are members of the tumour necrosis factor superfamily. We have examined circulating BAFF and APRIL in relation to serological deviati...
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Article
Programmed Cell Death of Peripheral Blood B Cells Determined by Laser Scanning Cytometry in Sjögren’s Syndrome with a Special Emphasis on BAFF
Functionally impaired B cells play an important role in the pathogenesis of Sjögren’s syndrome (SS). The aim of the study was to investigate the apoptosis susceptibility of peripheral blood B cells from patien...
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Article
Increased Expression of Fas Ligand on Mycobacterium tuberculosis Infected Macrophages: A Potential Novel Mechanism of Immune Evasion by Mycobacterium tuberculosis?
We have studied the location and mechanism of apoptosis within the granulomas in the lungs at various stages of slowly progressive primary murine Mycobacterium tuberculosis infection. Parallel sections were analy...