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Article
Open AccessEffect of sodium bicarbonate supplementation on the renin-angiotensin system in patients with chronic kidney disease and acidosis: a randomized clinical trial
Acidosis-induced kidney injury is mediated by the intrarenal renin-angiotensin system, for which urinary renin is a potential marker. Therefore, we hypothesized that sodium bicarbonate supplementation reduces ...
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Article
A population-based study on the prevalence and incidence of chronic kidney disease in the Netherlands
Because most population-based studies on the epidemiology of chronic kidney disease (CKD) are cross-sectional, there is, except for end-stage renal disease, hardly any information on incidence rates.
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Article
Disorders of calcium and magnesium balance: a physiology-based approach
Disorders of calcium and magnesium balance are physiologically interesting and clinically challenging. In this review, we attempt to bridge the gap between physiology and practice by providing a physiology-bas...
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Article
Estimation of the glomerular filtration rate in children: which algorithm should be used?
Glomerular filtration rate (GFR) in children can be estimated by the formula GFR=k×BH/Pcr (where BH is body height in centimetres and Pcr is the plasma creatinine concentration in micromoles per litre). For k,...
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Article
Determination of inulin clearance by single injection or infusion in children
The reference method to determine the glomerular filtration rate (GFR) in children is the urinary clearance of inulin during a continuous intravenous infusion. Alternatively, the plasma clearance of inulin can...