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Article
Open AccessNurse-led self-management support after organ transplantation—protocol of a multicentre, stepped-wedge randomized controlled trial
Recipients of an organ transplantation face a number of challenges and often need to change their health behaviour. Good self-management skills are essential for optimal clinical outcomes. However, few interve...
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Article
Open AccessEffect of sodium bicarbonate supplementation on the renin-angiotensin system in patients with chronic kidney disease and acidosis: a randomized clinical trial
Acidosis-induced kidney injury is mediated by the intrarenal renin-angiotensin system, for which urinary renin is a potential marker. Therefore, we hypothesized that sodium bicarbonate supplementation reduces ...
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Article
Open AccessComparison of a home-based (multi) systemic intervention to promoting Medication AdheRence and Self-management among kidney transplant recipients with care-as-usual: the MARS randomized controlled trial protocol
After kidney transplantation non-adherence and inadequate self-management undermine clinical outcomes and quality of life. Both have been demonstrated to be substantial in all age groups. However, intervention...
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Article
Open AccessSerum magnesium and the risk of prediabetes: a population-based cohort study
Previous studies have found an association between serum magnesium and incident diabetes; however, this association may be due to reverse causation, whereby diabetes may induce urinary magnesium loss. In contr...
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Article
Open AccessHepatic Cyst Infection During Use of the Somatostatin Analog Lanreotide in Autosomal Dominant Polycystic Kidney Disease: An Interim Analysis of the Randomized Open-Label Multicenter DIPAK-1 Study
The DIPAK-1 Study investigates the reno- and hepatoprotective efficacy of the somatostatin analog lanreotide compared with standard care in patients with later stage autosomal dominant polycystic kidney diseas...
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Article
Open AccessBone Mineral Density in Sjögren Syndrome Patients with and Without Distal Renal Tubular Acidosis
Primary Sjögren’s syndrome (pSS) can be complicated by distal renal tubular acidosis (dRTA), which may contribute to low bone mineral density (BMD). Our objective was to evaluate BMD in pSS patients with and ...
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Article
Open AccessA series of patients with minimal change nephropathy treated with rituximab during adolescence and adulthood
The treatment of immune suppression dependent minimal change nephropathy (MCN) can be challenging and frequently leads to serious complications. In paediatric patients, successful treatment with rituximab is d...
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Article
Erratum to: Clinical practice guideline on diagnosis and treatment of hyponatraemia
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Article
Open AccessEverything you need to know about distal renal tubular acidosis in autoimmune disease
Renal acid–base homeostasis is a complex process, effectuated by bicarbonate reabsorption and acid secretion. Impairment of urinary acidification is called renal tubular acidosis (RTA). Distal renal tubular a...
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Article
Erratum to: Clinical practice guideline on diagnosis and treatment of hyponatraemia
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Article
Open AccessConscious versus unconscious thinking in the medical domain: the deliberation-without-attention effect examined
Previous studies have shown that with important decisions, unconscious thought has surprisingly led to better choices than conscious thought. The present study challenges this so-called ‘deliberation-without-a...
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Article
A population-based study on the prevalence and incidence of chronic kidney disease in the Netherlands
Because most population-based studies on the epidemiology of chronic kidney disease (CKD) are cross-sectional, there is, except for end-stage renal disease, hardly any information on incidence rates.
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Article
Clinical practice guideline on diagnosis and treatment of hyponatraemia
Hyponatraemia, defined as a serum sodium concentration <135 mmol/L, is the most common disorder of body fluid and electrolyte balance encountered in clinical practice. Hyponatraemia is present in 15–20 % of em...
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Article
The sodium chloride cotransporter SLC12A3: new roles in sodium, potassium, and blood pressure regulation
SLC12A3 encodes the thiazide-sensitive sodium chloride cotransporter (NCC), which is primarily expressed in the kidney, but also in intestine and bone. In the kidney, NCC is located in the apical...
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Article
Disorders of calcium and magnesium balance: a physiology-based approach
Disorders of calcium and magnesium balance are physiologically interesting and clinically challenging. In this review, we attempt to bridge the gap between physiology and practice by providing a physiology-bas...
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Article
Urinary Markers of Intrarenal Renin-Angiotensin System Activity In Vivo
Recent interest focuses on urinary renin and angiotensinogen as markers of renal renin-angiotensin system activity. Before concluding that these components are independent markers, we need to exclude that thei...
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Article
Open AccessDistal renal tubular acidosis in primary Sjögren syndrome
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Article
Open AccessAldosterone does not require angiotensin II to activate NCC through a WNK4–SPAK–dependent pathway
We and others have recently shown that angiotensin II can activate the sodium chloride cotransporter (NCC) through a WNK4–SPAK-dependent pathway. Because WNK4 was previously shown to be a negative regulator of...
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Article
Hyponatremia and bone: an emerging relationship
Recent studies suggest previously unrecognized complications of hyponatremia, including falls, osteoporosis and fractures, and show that hyponatremia can have direct effects on bone, mainly via activation of o...
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Article
A case of primary aldosteronism revealed after renal transplantation
This article reports the case of a 57-year-old woman who was diagnosed with primary aldosteronism after renal transplantation. The authors discuss the challenges of diagnosing this syndrome in patients with ch...
