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Article
Early corticosteroid withdrawal is associated with improved adult height in pediatric kidney transplant recipients
Catch-up growth after pediatric kidney transplantation (kTx) is usually insufficient to reach normal adult height. We aimed to analyze the effect of pre-transplant recombinant human growth hormone (rhGH) and c...
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Article
Body mass index is associated with hyperparathyroidism in pediatric kidney transplant recipients
Hyperparathyroidism persists in up to 50% of pediatric kidney transplant recipients. The aims of this study were to describe the evolution of parathyroid hormone (PTH) in the first year after transplantation a...
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Article
Use of amlodipine oral solution for the treatment of hypertension in children
Background Amlodipine is a widely used antihypertensive agent for the treatment of paediatric hypertension, but the commercially available tablets are not suitable to treat young patients, who need lower, flexibl...
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Article
Open AccessA Population Pharmacokinetic Model Does Not Predict the Optimal Starting Dose of Tacrolimus in Pediatric Renal Transplant Recipients in a Prospective Study: Lessons Learned and Model Improvement
Bodyweight-based dosing of tacrolimus is considered standard care. Currently, at first steady state, a third of pediatric kidney transplant recipients has a tacrolimus pre-dose concentration within the target ...
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Article
Drug-metabolizing enzymes CYP3A as a link between tacrolimus and vitamin D in renal transplant recipients: is it relevant in clinical practice?
CYP3A enzymes are involved in the metabolism of calcineurin inhibitor tacrolimus as well as vitamin D. In this review, we summarize the clinical aspects of CYP3A-mediated metabolism of tacrolimus and vitamin D...
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Article
Open AccessChildren on dialysis as well as renal transplanted children report severely impaired health-related quality of life
To assess health-related quality of life (HRQoL) across three renal replacement therapy modalities (preemptive transplant, non-preemptive transplant, and dialysis) in comparison with the healthy norm and other...
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Article
Open AccessA Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation
Multiple clinical, demographic, and genetic factors affect the pharmacokinetics of tacrolimus in children, yet in daily practice, a uniform body-weight based starting dose is used. It can take weeks to reach t...
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Article
The Effect of Weight and CYP3A5 Genotype on the Population Pharmacokinetics of Tacrolimus in Stable Paediatric Renal Transplant Recipients
The aim of this study was to develop a population pharmacokinetic model of tacrolimus in paediatric patients at least 1 year after renal transplantation and simulate individualised dosage regimens.
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Article
Open AccessThe impact of estimated glomerular filtration rate equations on chronic kidney disease staging in pediatric renal or heart transplant recipients
The aim of this study was to evaluate the performance of selected pediatric estimated glomerular filtration rate (eGFR) equations in relation to the clinical management of children after renal or heart transpl...
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Article
Open AccessUrinary neutrophil gelatinase-associated lipocalin identifies critically ill young children with acute kidney injury following intensive care admission: a prospective cohort study
Children admitted to a pediatric intensive care unit (ICU) are at high risk of develo** acute kidney injury (AKI). Although serum creatinine (SCr) levels are used in clinical practice, they are insensitive f...
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Article
Open AccessPharmacokinetics of rituximab in a pediatric patient with therapy-resistant nephrotic syndrome
Rituximab (RTX) has recently been introduced as a second-line therapy for nephrotic syndrome in children. Studies show that RTX given during the nephrotic state may be less effective than treatment during a no...
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Article
Loop diuretics are an independent risk factor for acute kidney injury in children on extracorporeal membrane oxygenation with pre-emptive continuous hemofiltration
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Article
Open AccessAcute kidney injury is a frequent complication in critically ill neonates receiving extracorporeal membrane oxygenation: a 14-year cohort study
Newborns in need of extracorporeal membrane oxygenation (ECMO) support are at high risk of develo** acute kidney injury (AKI). AKI may occur as part of multiple organ failure and can be aggravated by exposur...
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Article
Policy variation in donor and recipient status in 11 pediatric renal transplantation centers
Evidence-based guidelines for pediatric renal transplantation (Tx) are lacking. This may lead to unwanted treatment variations. We aimed to quantify the variation in treatment policies and its consequences in ...
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Article
Management policies for children with renal transplantation in the Netherlands, Belgium and Germany – Report from the RICH-Q study
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Article
Open AccessDisparities in dialysis treatment and outcomes for Dutch and Belgian children with immigrant parents
In Belgium and the Netherlands, up to 40% of the children on dialysis are children with immigrant parents of non-Western European origin (non-Western). Concerns exist regarding whether these non-Western patien...
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Article
Open AccessEculizumab as rescue therapy for atypical hemolytic uremic syndrome with normal platelet count
Atypical hemolytic uremic syndrome (aHUS) in childhood is a rare disease with frequent progression to end-stage renal disease and a high recurrence after kidney transplantation. Eculizumab, a humanized monoclo...
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Article
Open AccessReference values for serum creatinine in children younger than 1 year of age
Reliable reference values of enzymatically assayed serum creatinine categorized in small age intervals are lacking in young children. The aim of this study was to determine reference values for serum creatinin...
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Article
Open AccessSchimke immunoosseous dysplasia: defining skeletal features
Schimke immunoosseous dysplasia (SIOD) is an autosomal recessive multisystem disorder characterized by prominent spondyloepiphyseal dysplasia, T cell deficiency, and focal segmental glomerulosclerosis. Biallel...
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Article
Open AccessHaemofiltration in newborns treated with extracorporeal membrane oxygenation: a case-comparison study
Extracorporeal membrane oxygenation is a supportive cardiopulmonary bypass technique for patients with acute reversible cardiovascular or respiratory failure. Favourable effects of haemofiltration during cardi...
