8 Result(s)
within
Robert L Martuza
English
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Article
Open AccessCharacterization and oncolytic virus targeting of FAP-expressing tumor-associated pericytes in glioblastoma
Cancer-associated fibroblasts (CAFs) are activated fibroblasts constituting the major stromal components in many types of cancer. CAFs contribute to hallmarks of cancer such as proliferation, invasion and immu...
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Article
Open AccessMyc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma
PARP inhibitors (PARPis) have clinical efficacy in BRCA-deficient cancers, but not BRCA-intact tumors, including glioblastoma (GBM). We show that MYC or MYCN amplification in patient-derived glioblastoma stem-lik...
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Article
Author Correction: Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors
In the version of this article originally published, the figure callout in this sentence was incorrect: “Furthermore, in S1P1-KI mice themselves, whereas PD-1 blockade was ineffectual as monotherapy, the effec...
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Article
Open AccessGenetically distinct glioma stem-like cell xenografts established from paired glioblastoma samples harvested before and after molecularly targeted therapy
Intratumoural heterogeneity underlies tumour escape from molecularly targeted therapy in glioblastoma. A cell-based model preserving the evolving molecular profiles of a tumour during treatment is key to under...
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Article
Open AccessIdentification of diagnostic serum protein profiles of glioblastoma patients
Diagnosis of a glioblastoma (GBM) is triggered by the onset of symptoms and is based on cerebral imaging and histological examination. Serum-based biomarkers may support detection of GBM. Here, we explored ser...
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Article
Open AccessFlip-Flop HSV-BAC: bacterial artificial chromosome based system for rapid generation of recombinant herpes simplex virus vectors using two independent site-specific recombinases
Oncolytic herpes simplex virus (HSV) vectors that specifically replicate in and kill tumor cells sparing normal cells are a promising cancer therapy. Traditionally, recombinant HSV vectors have been generated ...
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Article
Replication-selective virotherapy for cancer: Biological principles, risk management and future directions
In the search for novel cancer therapies that can be used in conjunction with existing treatments, one promising area of research is the use of viral vectors and whole viruses. This review describes the underl...
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Article
Act locally, think globally
Locally growing malignant brain tumors provide a reasonable starting point for develo** targeted strategies of anti-cancer therapy (pages 1354–1368).
