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Article
A Monoclonal Antibody Against β1 Integrin Inhibits Proliferation and Increases Survival in an Orthotopic Model of High-Grade Meningioma
High-grade meningiomas (HGMs; World Health Organization [WHO] classification grade II and III) have high relapse rates and poor clinical outcomes despite surgery and radiation treatments. No effective medical ...
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Article
Author Correction: Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors
In the version of this article originally published, the figure callout in this sentence was incorrect: “Furthermore, in S1P1-KI mice themselves, whereas PD-1 blockade was ineffectual as monotherapy, the effec...
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Article
Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors
T cell dysfunction contributes to tumor immune escape in patients with cancer and is particularly severe amidst glioblastoma (GBM). Among other defects, T cell lymphopenia is characteristic, yet often attribut...
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Article
Replication-selective virotherapy for cancer: Biological principles, risk management and future directions
In the search for novel cancer therapies that can be used in conjunction with existing treatments, one promising area of research is the use of viral vectors and whole viruses. This review describes the underl...
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Article
Evaluation of ganciclovir-mediated enhancement of the antitumoral effect in oncolytic, multimutated herpes simplex virus type 1 (G207) therapy of brain tumors
G207 is a multimutated, conditionally replicating herpes simplex virus type 1 (HSV-1) that retains an intact viral thymidine kinase (HSV-tk) gene. The virus exhibits oncolytic activity in various tumors and is...
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Article
Act locally, think globally
Locally growing malignant brain tumors provide a reasonable starting point for develo** targeted strategies of anti-cancer therapy (pages 1354–1368).
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Article
Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas
We have created a double mutant of the herpes simplex virus (HSV) type 1 (termed G207) with favourable properties for treating human malignant brain tumours: replication–competence in glioblastoma cells (and o...