9 Result(s)
within
Robert L Martuza
Biomedicine
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Article
Open AccessCharacterization and oncolytic virus targeting of FAP-expressing tumor-associated pericytes in glioblastoma
Cancer-associated fibroblasts (CAFs) are activated fibroblasts constituting the major stromal components in many types of cancer. CAFs contribute to hallmarks of cancer such as proliferation, invasion and immu...
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Article
Author Correction: Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors
In the version of this article originally published, the figure callout in this sentence was incorrect: “Furthermore, in S1P1-KI mice themselves, whereas PD-1 blockade was ineffectual as monotherapy, the effec...
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Article
Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors
T cell dysfunction contributes to tumor immune escape in patients with cancer and is particularly severe amidst glioblastoma (GBM). Among other defects, T cell lymphopenia is characteristic, yet often attribut...
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Chapter
Viral Oncolysis of Glioblastoma
The current state of replication-competent or replication-selective oncolytic viral treatment of malignant astrocytomas is reviewed. This includes studies examining the DNA viruses herpes simplex type I and ad...
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Article
Replication-selective virotherapy for cancer: Biological principles, risk management and future directions
In the search for novel cancer therapies that can be used in conjunction with existing treatments, one promising area of research is the use of viral vectors and whole viruses. This review describes the underl...
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Article
Evaluation of ganciclovir-mediated enhancement of the antitumoral effect in oncolytic, multimutated herpes simplex virus type 1 (G207) therapy of brain tumors
G207 is a multimutated, conditionally replicating herpes simplex virus type 1 (HSV-1) that retains an intact viral thymidine kinase (HSV-tk) gene. The virus exhibits oncolytic activity in various tumors and is...
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Article
Act locally, think globally
Locally growing malignant brain tumors provide a reasonable starting point for develo** targeted strategies of anti-cancer therapy (pages 1354–1368).
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Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas
We have created a double mutant of the herpes simplex virus (HSV) type 1 (termed G207) with favourable properties for treating human malignant brain tumours: replication–competence in glioblastoma cells (and o...
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Chapter
Virus-Mediated Genetic Treatment of Rodent Gliomas
The most common primary central nervous system neoplasm in adults is the malignant glioma. Approximately 5,000 new cases are diagnosed annually in the United States. This tumor has proven to be extremely refra...
