-
Article
An evidence-based screening tool for heart failure with preserved ejection fraction: the HFpEF-ABA score
Heart failure with preserved ejection fraction (HFpEF) is under-recognized in clinical practice. Although a previously developed risk score, termed H2FPEF, can be used to estimate HFpEF probability, this score re...
-
Article
Nimodipine-associated standard dose reductions and neurologic outcomes after aneurysmal subarachnoid hemorrhage: the era of pharmacogenomics
Nimodipine, an L-type cerebroselective calcium channel antagonist, is the only drug approved by the US Food and Drug Administration for the neuroprotection of patients with aneurysmal subarachnoid hemorrhage (...
-
Article
Open AccessArtificial intelligence-enabled ECG for left ventricular diastolic function and filling pressure
Assessment of left ventricular diastolic function plays a major role in the diagnosis and prognosis of cardiac diseases, including heart failure with preserved ejection fraction. We aimed to develop an artific...
-
Article
Perceived Age as a Mortality and Comorbidity Predictor: A Systematic Review
Perceived age is defined as how old a person looks to external evaluators. It reflects the underlying biological age, which is a measure based on physical and physiological parameters reflecting a person’s agi...
-
Article
Prospective evaluation of smartwatch-enabled detection of left ventricular dysfunction
Although artificial intelligence (AI) algorithms have been shown to be capable of identifying cardiac dysfunction, defined as ejection fraction (EF) ≤ 40%, from 12-lead electrocardiograms (ECGs), identificatio...
-
Article
Magnetic resonance imaging (MRI) helps differentiate renal cell carcinoma with sarcomatoid differentiation from renal cell carcinoma without sarcomatoid differentiation
The aim of the present study is to identify predictive imaging findings and construct a diagnostic model for differentiating renal cell carcinoma (RCC) with and without sarcomatoid dedifferentiation (sRCC and ...
-
Article
Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19
-
Article
Open AccessMortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors
Successful therapeutics and vaccines for coronavirus disease 2019 (COVID-19) have harnessed the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidence that SARS-CoV-2 exists ...
-
Article
NIH funding trends for neurosurgeon-scientists from 1993–2017: Biomedical workforce implications for neurooncology
Neurosurgeons represent 0.5% of all physicians and currently face a high burden of disease. Physician-scientists are essential to advance the mission of National Academies of Science (NAS) and National Institu...
-
Article
Open AccessPrediction of short-term antidepressant response using probabilistic graphical models with replication across multiple drugs and treatment settings
Heterogeneity in the clinical presentation of major depressive disorder and response to antidepressants limits clinicians’ ability to accurately predict a specific patient’s eventual response to therapy. Valid...
-
Article
Open AccessTranscriptomic analysis to identify genes associated with selective hippocampal vulnerability in Alzheimer’s disease
Selective vulnerability of different brain regions is seen in many neurodegenerative disorders. The hippocampus and cortex are selectively vulnerable in Alzheimer’s disease (AD), however the degree of involvem...
-
Article
The evolving role of imaging for small bowel neuroendocrine neoplasms: estimated impact of imaging and disease-free survival in a retrospective observational study
To determine how small bowel neuroendocrine neoplasms (SBNEN’s) are diagnosed and examine the effect of CT enterography (CTE) on diagnosis and rates of disease-free survival.
-
Article
Prior iterative reconstruction (PIR) to lower radiation dose and preserve radiologist performance for multiphase liver CT: a multi-reader pilot study
Prior iterative reconstruction (PIR) spatially registers CT image data from multiple phases of enhancement to reduce image noise. We evaluated PIR in contrast-enhanced multiphase liver CT.
-
Article
Open AccessPragmatic considerations for fostering reproducible research in artificial intelligence
Artificial intelligence and deep learning methods hold great promise in the medical sciences in areas such as enhanced tumor identification from radiographic images, and natural language processing to extract ...
-
Article
Screening for cardiac contractile dysfunction using an artificial intelligence–enabled electrocardiogram
Asymptomatic left ventricular dysfunction (ALVD) is present in 3–6% of the general population, is associated with reduced quality of life and longevity, and is treatable when found1–4. An inexpensive, noninvasive...
-
Article
Open AccessSex and age interact to determine clinicopathologic differences in Alzheimer’s disease
Women reportedly make up two-thirds of Alzheimer’s disease (AD) dementia sufferers. Many estimates regarding AD, however, are based on clinical series lacking autopsy confirmation. The Florida Autopsied Multi-...
-
Article
Open AccessQuantitative background parenchymal uptake on molecular breast imaging and breast cancer risk: a case-control study
Background parenchymal uptake (BPU), which refers to the level of Tc-99m sestamibi uptake within normal fibroglandular tissue on molecular breast imaging (MBI), has been identified as a breast cancer risk fact...
-
Article
Decreased Skeletal Muscle Volume Is a Predictive Factor for Poorer Survival in Patients Undergoing Surgical Resection for Pancreatic Ductal Adenocarcinoma
The aim of this study was to investigate the impact of decreased skeletal muscle (SM) volume on survival outcomes in patients undergoing surgical resection for pancreatic ductal adenocarcinoma (PDAC).
-
Article
Validation study of a new semi-automated software program for CT body composition analysis
Computed tomography (CT) has been increasingly used to quantify abdominal muscle and fat in clinical research studies, and multiple studies have shown importance of body composition in predicting clinical outc...
-
Article
Open AccessMeasuring the impact of ambulatory red blood cell transfusion on home functional status: study protocol for a pilot randomized controlled trial
Red blood cell (RBC) transfusion is frequently employed in both ambulatory and hospital environments with the aim of improving patient functional status. In the ambulatory setting, this practice is particularl...
