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  1. Article

    Open Access

    Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade

    Immune checkpoint blockade (ICB) has demonstrated efficacy in patients with melanoma, but many exhibit poor responses. Using single cell RNA sequencing of melanoma patient-derived circulating tumor cells (CTCs...

    Douglas B. Fox, Richard Y. Ebright, **n Hong, Hunter C. Russell… in npj Precision Oncology (2023)

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  2. Article

    Open Access

    HIF1A signaling selectively supports proliferation of breast cancer in the brain

    Blood-borne metastasis to the brain is a major complication of breast cancer, but cellular pathways that enable cancer cells to selectively grow in the brain microenvironment are poorly understood. We find tha...

    Richard Y. Ebright, Marcus A. Zachariah, Douglas S. Micalizzi… in Nature Communications (2020)

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  3. No Access

    Article

    HER2 expression identifies dynamic functional states within circulating breast cancer cells

    Patient-derived circulating tumour cells are used to characterize the dynamics and underlying plasticity of HER2 expression in non-HER2-amplified breast tumours.

    Nicole Vincent Jordan, Aditya Bardia, Ben S. Wittner, Cyril Benes, Matteo Ligorio… in Nature (2016)