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Open AccessSingle-cell sequencing of a novel model of neonatal bile duct ligation in mice identifies macrophage heterogeneity in obstructive cholestasis
Macrophages (MΦ) play a role in neonatal etiologies of obstructive cholestasis, however, the role for precise MΦ subsets remains poorly defined. We developed a neonatal murine model of bile duct ligation (BDL)...
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Open AccessAuthor Correction: Complex bile duct network formation within liver decellularized extracellular matrix hydrogels
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Article
Open AccessExpression of unfolded protein response genes in post-transplantation liver biopsies
Cholestatic liver diseases are a major source of morbidity and mortality that can progress to end-stage liver disease and hyperbilirubinemia is a hallmark of cholestasis. There are few effective medical therap...
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Article
Open AccessComplex bile duct network formation within liver decellularized extracellular matrix hydrogels
The biliary tree is an essential component of transplantable human liver tissue. Despite recent advances in liver tissue engineering, attempts at re-creating the intrahepatic biliary tree have not progressed s...
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Article
Open AccessCorrection to: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma
Following publication of the original article [1], the authors reported an error in the spelling of one of the author names. In this Correction the incorrect and correct author names are indicated and the auth...
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Article
Open AccessFirst results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma
Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax®-L) to standard the...
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Article
Open AccessMultimodal Imaging of Nanocomposite Microspheres for Transcatheter Intra-Arterial Drug Delivery to Liver Tumors
A modern multi-functional drug carrier is critically needed to improve the efficacy of image-guided catheter-directed approaches for the treatment of hepatic malignancies. For this purpose, a nanocomposite mic...
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Open AccessA dose escalation trial for the combination of erlotinib and sirolimus for recurrent malignant gliomas
In order to achieve higher dosages than previously used in clinical trials, we conducted a phase I trial to determine the maximum tolerated dose (MTD) for the combination of erlotinib and sirolimus for the tre...
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Article
Open AccessRosette-forming glioneuronal tumor: a pineal region case with IDH1 and IDH2 mutation analyses and literature review of 43 cases
Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a mixed glio-neuronal neoplasm recently codified by the World Health Organization WHO Classification of Central Nervous System (CNS) Tumors (20...
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Article
Open AccessPancreatic adenocarcinoma in type 2 progressive familial intrahepatic cholestasis
BSEP disease results from mutations in ABCB11, which encodes the bile salt export pump (BSEP). BSEP disease is associated with an increased risk of hepatobiliary cancer.
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Article
Open AccessBile composition in Alagille Syndrome and PFIC patients having Partial External Biliary Diversion
Partial External Biliary Diversion (PEBD) is a surgical intervention to treat children with Progressive Familial Intrahepatic Cholestasis (PFIC) and Alagille syndrome (AGS). PEBD can reduce disease progression...
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Article
Mice overexpressing hepatic Abcb11 rapidly develop cholesterol gallstones
Cholelithiasis is a polygenic disease, although the genes responsible for gallstone formation have not yet been clearly identified. QTL analysis has identified the Lith 1 loci on mouse Chromosome 2, and the hepat...
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Article
Microarray analysis of hepatic gene expression in gallstone-susceptible and gallstone-resistant mice
Cholesterol gallstone disease affects 40 million Americans, and evidence indicates that there is a genetic component to human gallstone disease. In a mouse model of gallstone formation, where mice are fed a li...
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Article
Optimal Operative Strategies in Repair of Juxtarenal Abdominal Aortic Aneurysms
In an effort to identify preoperative and perioperative factors impacting outcome in repair of juxtarenal abdominal aortic aneurysm (JRAAA), hospital records and CT scans (for calcification, intraluminal throm...
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Article
EEG Changes during Awake Carotid Endarterectomy
To determine the reason for differing shunt rates based on electroencephalographic (EEG) and neurologic changes during general and regional anesthetic, respectively, we compared simultaneous EEG tracings and n...
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Clinical Implications of Internal Iliac Artery Embolization in Endovascular Repair of Aortoiliac Aneurysms
To overcome constraints imposed by iliac artery anatomy, the anatomic inclusion criteria for endovascular aortic aneurysm repair can be extended by means of intentional coil occlusion of one or both internal i...
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Article
External Beam Irradiation for Inhibition of Intimal Hyperplasia following Prosthetic Bypass: Preliminary Results
To determine whether external beam irradiation delivered immediately after graft implantation can inhibit anastomotic intimal hyperplasia (IH) 1 month following polytetrafluoroethylene (PTFE) bypass in a sheep...
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Alcohol Withdrawal after Open Aortic Surgery
