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Article
Open AccessCorrection: Efficient pathway for men fertility preservation in testicular cancer or lymphoma: a cross-sectional study of national 2018 data
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Article
Open AccessEfficient pathway for men fertility preservation in testicular cancer or lymphoma: a cross-sectional study of national 2018 data
In 15–49 years-old men, the main cancers are testicular cancer (TC) and lymphomas (L): freezing of ejaculated sperm is primarily used for male fertility preservation (FP) before cancer treatment.
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Article
Determination of 5-azacitidine in human plasma by LC–MS/MS: application to pharmacokinetics pilot study in MDS/AML patients
Azacitidine (Vidaza®, AZA) is a mainstay for treating acute myeloid leukemia (AML) in patients unfit for standard induction and other myelodysplastic syndromes (MDS). However, only half of the patients usually...
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Article
Open AccessIntensive end-of-life care in acute leukemia from a French national hospital database study (2017–2018)
A better understanding of how the care of acute leukemia patients is managed in the last days of life would help clinicians and health policy makers improve the quality of end-of-life care. This study aimed: (...
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Article
Clinical characteristics and outcomes of patients with haematologic malignancies and COVID-19 suggest that prolonged SARS-CoV-2 carriage is an important issue
Specificities of COVID-19 disease course in patients with haematologic malignancies are still poorly studied. So, we aimed to compare patients with haematologic malignancies to patients without malignancies, m...
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Article
Open AccessThe contribution of single-cell analysis of acute leukemia in the therapeutic strategy
After decades during which the treatment of acute myeloblastic leukemia was limited to variations around a skeleton of cytarabine/anthracycline, targeted therapies appeared. These therapies, first based on mon...
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Article
Open AccessDual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer
Aldehyde dehydrogenases (ALDHs) are multifunctional enzymes that oxidize diverse endogenous and exogenous aldehydes. We conducted a meta-analysis based on The Cancer Genome Atlas and Gene Expression Omnibus data ...
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Article
Open AccessFirst case of B ALL with KMT2A-MAML2 rearrangement: a case report
A large number of chromosomal translocations of the human KMT2A gene, better known as the MLL gene, have so far been characterized. Genetic rearrangements involving KMT2A gene are frequently involved in lymphoid,...
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Article
Open AccessSepsis 2016 Paris
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Open AccessMixed Streptococcus pneumoniae and Streptococcus pyogenes meningitis in an immunocompromised adult patient: a case report
Community-acquired meningitis is a monomicrobial infection caused by either viruses or bacteria in the vast majority of patients. We report here one exceptional case of a patient with mixed bacterial meningiti...
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Hemolytic Anemias Resuscitation in Adults
Hemolytic anemia is a rare disease classified as constitutional or acquired. This classification allows clinicians to adapt treatment to each type of etiology. The diagnosis of hemolysis itself relies on the o...
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Article
Recurrent superior vena cava syndrome caused by IgD multiple myeloma
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Anémies hémolytiques en réanimation chez l’adulte
Les anémies hémolytiques par anomalie de la membrane érythrocytaire sont diagnostiquées par l’observation du frottis sanguin à la recherche d’anomalies mor...
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Article
Human CD28 and CTLA-4 Ig superfamily genes are located on chromosome 2 at bands q33–q34
CD28 is a cell surface molecule present on most peripheral T cells which has been implied in the amplification of the T-cell response in vitro. Using in situ hybridization on human prometaphase cells, we have ...
