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Article
Possible role of small secreted peptides (SSPs) in immune signaling in bryophytes
Plants utilize a plethora of peptide signals to regulate their immune response. Peptide ligands and their cognate receptors involved in immune signaling share common motifs among many species of vascular plant...
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Article
Open AccessPhytohormone treatment induces generation of cryptic peptides with antimicrobial activity in the Moss Physcomitrella patens
Cryptic peptides (cryptides) are small bioactive molecules generated via degradation of functionally active proteins. Only a few examples of plant cryptides playing an important role in plant defense have been...
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Chapter
Design of Powerful DCDC Converters with Nanopower Consumption
Presented are structural and circuit techniques for DCDC converters with consumption below power switch leakage and having efficiency above 80% at load currents from few μA to 100 s of mA. These techniques hav...
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Protocol
Analysis of Endogenous Peptide Pools of Physcomitrella patens Moss
Here, we report our approach to peptidomic analysis of the plant object which led to structure elucidation of the title peptides. P. patens samples were extracted under conditions preventing proteolytic digestion...
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Article
Open AccessMixed Streptococcus pneumoniae and Streptococcus pyogenes meningitis in an immunocompromised adult patient: a case report
Community-acquired meningitis is a monomicrobial infection caused by either viruses or bacteria in the vast majority of patients. We report here one exceptional case of a patient with mixed bacterial meningiti...
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Chapter and Conference Paper
Reasoning over Ontologies and Non-monotonic Rules
Ontology languages and non-monotonic rule languages are both well-known formalisms in knowledge representation and reasoning, each with its own distinct benefits and features which are quite orthogonal to each...
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Chapter and Conference Paper
A Query Tool for \(\mathcal{EL}\) with Non-monotonic Rules
We present the Protégé plug-in NoHR that allows the user to take an \(\mathcal{EL}^+_\top\) ontology, add a set of non-...
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Article
Primary B-CLL Resistance to NK Cell Cytotoxicity can be Overcome In Vitro and In Vivo by Priming NK Cells and Monoclonal Antibody Therapy
Despite recent advances with monoclonal antibody therapy, chronic lymphocytic leukemia (CLL) remains incurable. Natural killer (NK) cells are potent antitumoral effectors, particularly against hematological ma...
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Chapter
Design Methodology and Circuit Techniques for Any-Load Stable LDOs with Instant Load Regulation and Low Noise
Application of the structural methodology to the LDO design creates a new class of circuits: any load stable, with instant transient response, large power supply rejection and low noise. Presented are examples...
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Article
Inhibitory effects of a nutrient mixture on human testicular cancer cell line NT 2/DT matrigel invasion and MMP activity
Current treatment of testicular cancer is associated with secondary malignancy, infertility, and cytotoxicity. Based on reported antimetastatic potential, we investigated the effect of a nutrient mixture (NM) ...
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Article
Inhibition of glioma cell line A-172 MMP activity and cell invasion in vitro by a nutrient mixture
Standard multimodality therapy of gliomas is associated with poor patient survival and significant toxicity. Abnormal expression of matrix metalloproteinases is associated with tumor growth and invasion. Based...
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Article
Effect of ascorbic acid, lysine, proline and green tea extract on human osteosarcoma cell line MNNG-HOS xenografts in nude mice
Structural changes in the extracellular matrix (ECM) are necessary for cell migration during tissue remodeling MMPs, VEGF, Ki-67 (proliferative protein), and constitutents of ECM play a critical role in angiog...
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Article
Modulation of human renal cell carcinoma 786-0 MMP-2 and MMP-9 activity by inhibitors and inducers in vitro
A hallmark of renal cell carcinoma (RCC) invasion is its ability to degrade ECM by local production of gelatinase enzymes. Although many studies on RCC have demonstrated the importance of MMPs, very little inf...
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Article
In vivo and in vitro antitumor effect of ascorbic acid, lysine, proline, arginine, and green tea extract on human fibrosarcoma cells HT-1080
Current treatment of fibrosarcoma, an aggressive cancer of the connective tissue, is generally associated with poor prognosis. Matrix metalloproteinases (MMPs), vascular endothelial growth factor (VEGF), and c...
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Article
In vitro and in vivo antitumorigenic activity of a mixture of lysine, proline, ascorbic acid, and green tea extract on human breast cancer lines MDA-MB-231 and MCF-7
Current treatments are generally ineffective once breast cancer has metastasized; median survival is reduced to 2–3 yr. Previous research studies demonstrating potent synergistic antitumor activity of lysine, ...
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Article
Antitumor effect of a combination of lysine, proline, arginine, ascorbic acid, and green tea extract on pancreatic cancer cell line MIA PaCa-2
Background: Current treatment of pancreatic cancer is generally associated with poor prognosis, even if diagnosed early, owing to its aggressive rate of metastasis and non-responsiveness to chemo...
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Article
Open AccessModulation of N-methyl-N-nitrosourea induced mammary tumors in Sprague–Dawley rats by combination of lysine, proline, arginine, ascorbic acid and green tea extract
The limited ability of current treatments to control metastasis and the proposed antitumor properties of specific nutrients prompted us to examine the effect of a specific formulation (nutrient supplement [NS]...
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Article
Class AB Output Stages of the Integrated Amplifiers
General approach to the design of the class AB output stages of bipolar and CMOS amplifiers based on common-mode negative feedback is discussed. Frequency compensation of the result multiloop system is provide...
