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Article
Structural basis of unidirectional export of lipopolysaccharide to the cell surface
Gram-negative bacteria are surrounded by an inner cytoplasmic membrane and by an outer membrane, which serves as a protective barrier to limit entry of many antibiotics. The distinctive properties of the outer...
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Article
Open AccessA cysteine-based molecular code informs collagen C-propeptide assembly
Fundamental questions regarding collagen biosynthesis, especially with respect to the molecular origins of homotrimeric versus heterotrimeric assembly, remain unanswered. Here, we demonstrate that the presence...
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Article
Balloon kyphoplasty in the management of vertebral compression fractures: an updated systematic review and meta-analysis
This systematic review updates the understanding of the evidence base for balloon kyphoplasty (BKP) in the management of vertebral compression fractures. Detailed searches of a number of electronic databases w...
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Article
Open AccessCritical appraisal skills training for health care professionals: a randomized controlled trial [ISRCTN46272378]
Critical appraisal skills are believed to play a central role in an evidence-based approach to health practice. The aim of this study was to evaluate the effectiveness and costs of a critical appraisal skills ...