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Open AccessCorrection: Cost Effectiveness of Endovascular Ultrasound Renal Denervation in Patients with Resistant Hypertension
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Open AccessCost Effectiveness of Endovascular Ultrasound Renal Denervation in Patients with Resistant Hypertension
Resistant hypertension (rHTN) is defined as blood pressure (BP) of ≥ 140/90 mmHg despite treatment with at least three antihypertensive medications, including a diuretic. Endovascular ultrasound renal denervat...
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Article
Protecting Newfoundland’s Palaeontological Geoheritage: Mitigating Anthropic and Environmental Damage to the Ediacaran Fossils of Upper Island Cove
Over 250 fossils belonging to the Ediacaran biota have been recognised from a single site in the town of Upper Island Cove, Newfoundland. These fossils preserve high-relief, sub...
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Open AccessThe IBER study: a feasibility randomised controlled trial of imagery based emotion regulation for the treatment of anxiety in bipolar disorder
Intrusive mental imagery is associated with anxiety and mood instability within bipolar disorder and therefore represents a novel treatment target. Imagery Based Emotion Regulation (IBER) is a brief structured...
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Open AccessSurrogate endpoints in trials: a call for better reporting
Using a surrogate endpoint as a substitute for a patient-relevant final outcome enables randomised controlled trials (RCTs) to be conducted more efficiently. However, the use of surrogates remains controversia...
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Open AccessA process evaluation, with mediation analysis, of a web-based intervention to augment primary care exercise referral schemes: the e-coachER randomised controlled trial
The e-coachER trial aimed to determine whether adding web-based behavioural support to exercise referral schemes (ERS) increased long-term device-measured physical activity (PA) for patients with chronic condi...
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Open AccessBenefits of cardiac rehabilitation following acute coronary syndrome for patients with and without diabetes: a systematic review and meta-analysis
The benefits of cardiac rehabilitation (CR) after acute coronary syndrome (ACS) are well established. However, the relative benefit of CR in those with comorbidities, including diabetes, is not well understood...
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Open AccessA pragmatic effectiveness-implementation study comparing trial evidence with routinely collected outcome data for patients receiving the REACH-HF home-based cardiac rehabilitation programme
Cardiac rehabilitation for heart failure continues to be greatly underused worldwide despite being a Class I recommendation in international clinical guidelines and uptake is low in women and patients with men...
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Open AccessEconomic evaluation of a complex intervention (Engager) for prisoners with common mental health problems, near to and after release: a cost-utility and cost-consequences analysis
People in prison experience a range of physical and mental health problems. Evaluating the effectiveness and efficiency of prison-based interventions presents a number of methodological challenges. We present ...
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The role of cardiac rehabilitation in improving cardiovascular outcomes
Cardiac rehabilitation is a complex intervention that seeks to improve the functional capacity, wellbeing and health-related quality of life of patients with heart disease. A substantive evidence base supports...
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Open AccessPsychological therapy for mood instability within bipolar spectrum disorder: a randomised, controlled feasibility trial of a dialectical behaviour therapy-informed approach (the ThrIVe-B programme)
A subgroup of those with bipolar spectrum disorders experience ongoing mood fluctuations outside of full episodes. We conducted a randomised, controlled feasibility study of a Dialectical Behavioural Therapy-i...
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A re-assessment of the taxonomy, palaeobiology and taphonomy of the rangeomorph organism Hapsidophyllas flexibilis from the Ediacaran of Newfoundland, Canada
Newfoundland’s Mistaken Point is home to some of the world’s oldest known complex body fossils. Detailed observation of newly discovered specimens has led to a reconsideration of Hapsidophyllas flexibilis, which ...
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Open AccessA simple cognitive task intervention to prevent intrusive memories after trauma in patients in the Emergency Department: A randomized controlled trial terminated due to COVID-19
This randomised controlled trial (RCT) aimed to investigate the effects of a simple cognitive task intervention on intrusive memories ("flashbacks") and associated symptoms following a traumatic event. Patient...
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Open AccessReducing intrusive memories after trauma via a brief cognitive task intervention in the hospital emergency department: an exploratory pilot randomised controlled trial
Intrusive memories are common after trauma, and can cause significant distress. Interventions to prevent/reduce the occurrence of this core clinical feature of posttraumatic stress disorder are needed; they sh...
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Open AccessProcess evaluation of a randomised pilot trial of home-based rehabilitation compared to usual care in patients with heart failure with preserved ejection fraction and their caregiver’s
Whilst almost 50% of heart failure (HF) patients have preserved ejection fraction (HFpEF), evidence-based treatment options for this patient group remain limited. However, there is growing evidence of the pote...
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Open AccessProceedings of the Virtual 3rd UK Implementation Science Research Conference
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Open AccessSurrogate Endpoints in Health Technology Assessment: An International Review of Methodological Guidelines
In the drive towards faster patient access to treatments, health technology assessment (HTA) agencies are increasingly faced with reliance on evidence from surrogate endpoints, leading to increased decision un...
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Open AccessThe role of cardiopulmonary exercise testing (CPET) in predicting mortality and morbidity in people with congenital heart disease: a systematic review and meta-analysis (Protocol)
Numerous studies have measured the prognostic associations between cardiorespiratory fitness and patient outcomes in congenital heart disease, but no systematic review has assessed these associations for all t...
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Open AccessPhysical activity assessment by accelerometry in people with heart failure
International guidelines for physical activity recommend at least 150 min per week of moderate-to-vigorous physical activity (MVPA) for adults, including those with cardiac disease. There is yet to be consensu...
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Open AccessThe value of social practice theory for implementation science: learning from a theory-based mixed methods process evaluation of a randomised controlled trial
Although there is trial evidence that complex interventions are effective for the self-management of heart failure, little evidence supports their effectiveness in routine practice. We used Social Practice The...
