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Open AccessAgeing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination
Myelin regeneration (remyelination) is essential to prevent neurodegeneration in demyelinating diseases such as Multiple Sclerosis, however, its efficiency declines with age. Regulatory T cells (Treg) recently...
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Brucella: Potential Biothreat Agent
Brucellosis is an ancient disease caused by brucellae, which are small, facultative, intracellular, gram-negative coccobacilli. Ten species of Brucella have been identified as the causative agents of brucellosis ...
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Open AccessThe E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome
The NLRP3 inflammasome has an important function in inflammation by promoting the processing of pro-IL-1β and pro-IL-18 to their mature bioactive forms, and by inducing cell death via pyroptosis. Here we show ...
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Regulatory T cells promote myelin regeneration in the central nervous system
Regeneration of myelin is a dynamic, yet enigmatic process. Dombrowski et al. uncover a central role for regulatory T (Treg) cells in driving oligodendrocyte differentiation, in part via CCN3, a novel factor in T
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Article
Open AccessNatural cutaneous anthrax infection, but not vaccination, induces a CD4+ T cell response involving diverse cytokines
Whilst there have been a number of insights into the subsets of CD4+ T cells induced by pathogenic Bacillus anthracis infections in animal models, how these findings relate to responses generated in naturally inf...
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Th1 not Th17 cells drive spontaneous MS-like disease despite a functional regulatory T cell response
Multiple sclerosis is considered a disease of complex autoimmune etiology, yet there remains a lack of consensus as to specific immune effector mechanisms. Recent analyses of experimental autoimmune encephalom...
