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Article
Nanoparticles Enhance Solubility and Neuroprotective Effects of Resveratrol in Demyelinating Disease
Resveratrol is a natural polyphenol which may be useful for treating neurodegenerative diseases such as multiple sclerosis (MS). To date, current immunomodulatory treatments for MS aim to reduce inflammation w...
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Article
Cell-Specific Expression of Human SIRT1 by Gene Therapy Reduces Retinal Ganglion Cell Loss Induced by Elevated Intraocular Pressure
SIRT1 prevents retinal ganglion cell (RGC) loss in several acute and subacute optic neuropathy models following pharmacologic activation or genetic overexpression. We hypothesized that adeno-associated virus (...
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Article
Open AccessRescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1
SIRT1 prevents retinal ganglion cell (RGC) loss in models of optic neuropathy following pharmacologic activation or genetic overexpression. The exact mechanism of loss is not known, prior evidence suggests thi...
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Article
Amnion-Derived Multipotent Progenitor Cells Suppress Experimental Optic Neuritis and Myelitis
The human amnion has been used for decades in wound healing, particularly burns. Amnion epithelial cells (AECs) have been the focus of extensive research based on their possible pluripotent differentiation abi...
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Article
Open AccessDexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis
Dysregulation of iron metabolism, and resultant cytotoxicity, has been implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative processes. Iron accumulation promotes cytotoxicity t...
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Article
Open AccessIntranasal Delivery of A Novel Amnion Cell Secretome Prevents Neuronal Damage and Preserves Function In A Mouse Multiple Sclerosis Model
The ability of a novel intranasally delivered amnion cell derived biologic to suppress inflammation, prevent neuronal damage and preserve neurologic function in the experimental autoimmune encephalomyelitis an...
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Article
Open AccessSIRT1 Activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease
Multiple sclerosis (MS) is characterized by central nervous system inflammation and demyelination, and increasing evidence demonstrates significant neuronal damage also occurs and is associated with permanent ...
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Article
Protective Role of Astrocytic Leptin Signaling Against Excitotoxicity
Both proconvulsive and anticonvulsive roles of leptin have been reported, suggesting cell-specific actions of leptin in different models of seizure and epilepsy. The goal of our study was to determine the regu...
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Article
Potential Protective Role of IL15Rα During Inflammation
We have shown that TNFα specifically activates the interleukin-15 (IL15) system in cerebral endothelial cells composing the blood–brain barrier. To determine the functions of cerebral IL15 signaling in inflamm...
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Article
IL-15 Receptor Deletion Results in Circadian Changes of Locomotor and Metabolic Activity
Interleukin-15 (IL-15) is a cytokine produced in the normal brain that acts on its specific receptor IL-15Rα and co-receptors IL-2Rβ and IL-2Rγ in neuronal cells. The functions of the cerebral IL-15 system, ho...
