14 Result(s)
within
Ramin Miri
Chemistry
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Article
Open AccessSynthesis and cytotoxic activity evaluation of novel imidazopyridine carbohydrazide derivatives
Two series of novel imidazo[1,2-a]pyridine-2-carbohydrazide derivatives have been designed, synthesized, and evaluated for cytotoxic activity. Target compounds were designed in two series: aryl hydrazone deriv...
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Open AccessSynthesis, biological evaluation and molecular docking analysis of vaniline–benzylidenehydrazine hybrids as potent tyrosinase inhibitors
In this work, 11 novel compounds based on vaniline and benzylidenehydrazine structure were synthesized with various substituents on phenyl aromatic ring of the molecule and evaluated as tyrosinase inhibitors. ...
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Virtual screening of some heterocyclic structures toward novel antibacterial agents
Infectious diseases and their treatment are among the most important issues in global health and economy. Moreover, increasing prevalence of antibiotic-resistant pathogenic bacteria necessitates the considera...
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Article
2-Imino 2H-chromene and 2-(phenylimino) 2H-chromene 3-aryl carboxamide derivatives as novel cytotoxic agents: synthesis, biological assay, and molecular docking study
The inhibition of AKR1B10 has been recognized as a potential therapeutic approach to the treatment of various types of cancers. A novel series of compounds with imino-2H-chromen and phenylimino-2H-chromen scaffol...
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Detailed atomistic molecular modeling of a potent type ΙΙ p38α inhibitor
The active site conservation among protein kinases makes it a real challenge to design selective inhibitors. In this regard, detailed understanding of structural features responsible for functional behavior of...
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A validated dispersive liquid-liquid microextraction method for extraction of ochratoxin A from raisin samples
A method based on dispersive liquid-liquid microextraction (DLLME) was developed for the quantitative extraction of Ochratoxin A (OTA) from raisin samples. The influence of various parameters on the recovery o...
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Molecular docking and quantum mechanical studies on biflavonoid structures as BACE-1 inhibitors
Beta-site amyloid precursor protein cleaving enzyme (BACE-1) is a well-known therapeutic target for Alzheimer disease (AD) due to its characteristic role in the pathogenesis of AD. Numerous researches have bee...
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Comparative hydrodistillation and headspace SPME-GC-MS analysis of volatile constituents of roots and shoots of Artemisia annua and Artemisia sieberi
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Evaluation of Dispersive Liquid–Liquid Microextraction–HPLC–UV for Determination of Deoxynivalenol (DON) in Wheat Flour
A fast and simple method for the extraction of deoxynivalenol (DON) from wheat flour using dispersive liquid–liquid microextraction (DLLME) followed by high-performance liquid chromatography–UV detection has b...
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Article
QM study and conformational analysis of an isatin Schiff base as a potential cytotoxic agent
Isatin is an important compound from the biological aspect of view. It is an endogenous substance and moreover; various pharmacological activities have been reported for isatin and its derivatives. In-vitro cy...
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Response surface methodology in docking study of small molecule BACE-1 inhibitors
Computational evaluation of ligand-receptor binding via docking strategy is a well established approach in structure-based drug design. This technique has been applied frequently in develo** molecules of bio...
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Article
Computer-aided design of novel antibacterial 3-hydroxypyridine-4-ones: application of QSAR methods based on the MOLMAP approach
3-Hydroxypyridine-4-one derivatives have shown good inhibitory activity against bacterial strains. In this work we report the application of MOLMAP descriptors based on empirical physicochemical properties wit...
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Quantitative structure–retention relationship study of analgesic drugs by application of combined data splitting-feature selection strategy and genetic algorithm-partial least square
The combined data splitting feature selection (CDFS) is a new strategy in quantitative structure–property relation (QSPR) analysis, in which the sampling of training set is performed repeatedly to find a subse...
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Article
Constituents of the essential oil of Scabiosa flavida from Iran
The composition of the essential oil of the aerial parts of Scabiosa flavida was investigated by GC and GC-MS. Forty-three components representing 94.2% of the essential oil were characterized. The main component...
