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  1. No Access

    Article

    Fokale dermale Hypoplasie durch pathogene Variante im PORCN-Gen in postzygotischer, unilateraler Mosaik-Konstellation

    Wir berichten über eine 29-jährige Patientin mit ab dem Grundschulalter bemerkbaren diskreten zum Teil erythematösen, zum Teil hyperpigmentierten Streifen entlang der Blaschko-Linien an der rechten Körperhälft...

    Eleni Koutra, Elke Lusmöller, Judith Fischer, Katalin Komlosi… in Die Dermatologie (2024)

  2. No Access

    Article

    Kutane Nebenwirkungen onkologischer Systemtherapien

    Bestimmte medikamentöse Tumortherapien verursachen kutane Toxizität an Händen, Füßen und Nägeln.

    Selma Ugurel, Prof. Dr. Claudia Pföhler, Ralf Gutzmer in Die Dermatologie (2024)

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    Article

    Combination of denosumab and immune checkpoint inhibition: experience in 29 patients with metastatic melanoma and bone metastases

    PD-1 inhibition (PD-1i) is the standard of care in melanoma and other malignancies. In patients with bone metastases of solid tumors, the monoclonal antibody denosumab directed against RANKL is approved for th...

    Yenny Angela, Sebastian Haferkamp, Carsten Weishaupt… in Cancer Immunology, Immunotherapy (2019)

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    Article

    First-line therapy-stratified survival in BRAF-mutant melanoma: a retrospective multicenter analysis

    Inhibition of the mitogen-activated protein kinase (MAPK) pathway as well as programmed death 1 receptor (PD-1) blockade was shown to prolong overall survival (OS) in patients with advanced B-Raf proto-oncogen...

    Bastian Schilling, Alexander Martens… in Cancer Immunology, Immunotherapy (2019)

  5. No Access

    Article

    The histamine H4 receptor modulates the differentiation process of human monocyte-derived M1 macrophages and the release of CCL4/MIP-1β from fully differentiated M1 macrophages

    Histamine is an important mediator of biological functions and present in high amounts in inflammatory skin lesions which are characterised by a marked infiltration of myeloid derived cell populations. The aim...

    Susanne Mommert, Lisanne Ratz, Holger Stark, Ralf Gutzmer… in Inflammation Research (2018)

  6. No Access

    Article

    Ipilimumab in metastatic melanoma patients with pre-existing autoimmune disorders

    Ipilimumab and programmed death (PD) 1-antibodies are effective treatment options in metastatic melanoma. The safety and efficacy of ipilimumab in patients with pre-existing autoimmune disorders (AD) has only ...

    Katharina C. Kähler, Thomas K. Eigentler… in Cancer Immunology, Immunotherapy (2018)

  7. Article

    Open Access

    Treatment of unresectable stage IV metastatic melanoma with aviscumine after anti-neoplastic treatment failure: a phase II, multi-centre study

    Aviscumine, a recombinant plant protein, is an immune modulator that induces ribotoxic stress at the 28S ribosomal RNA subunit. In this way cytokine release and T-cell responses are enhanced. This phase II tri...

    Uwe Trefzer, Ralf Gutzmer, Tabea Wilhelm… in Journal for ImmunoTherapy of Cancer (2014)

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    Article

    15. Mainzer Allergie-Workshop 2003

    Prof. Dr. J. Saloga, Prof. Dr. J. Knop, H. P. Rihs, B. Dumont… in Allergo Journal (2003)

  9. No Access

    Article

    Amikrobielle intertriginöse Pustulose bei Autoimmunerkrankungen – Eine neue Entität?

    Olliver Hoch, Rudolf A. Herbst, Ralf Gutzmer, Peter Kiehl, Alexander Kapp… in Der Hautarzt (1998)

  10. No Access

    Article

    Das Bart-Syndrom – Eigene Entität oder Variante einer Epidermolysis bullosa?

    Ralf Gutzmer, Rudolf A. Herbst, Jost Becker, Peter Kiehl… in Der Hautarzt (1997)

  11. No Access

    Article

    Das SAPHO-Syndrom Fallbeschreibung von drei Patienten mit Akne conglobata und osteoartikulären Symptomen

    Ralf Gutzmer, Rudolf A. Herbst, Alexander Kapp, Jürgen Weiß in Der Hautarzt (1997)