29 Result(s)
within
Sebastian Haferkamp
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Article
Open AccessRestricting datasets to classifiable samples augments discovery of immune disease biomarkers
Immunological diseases are typically heterogeneous in clinical presentation, severity and response to therapy. Biomarkers of immune diseases often reflect this variability, especially compared to their regulat...
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Article
Open AccessFistulising skin metastases in Crohn’s disease: a case report and review of the literature
Metastatic Crohn’s disease is a rare disorder characterized by various granulomatous skin lesions that occur independently of gastrointestinal tract involvement. However, currently there is no standardized car...
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Open AccessDermatologist-like explainable AI enhances trust and confidence in diagnosing melanoma
Artificial intelligence (AI) systems have been shown to help dermatologists diagnose melanoma more accurately, however they lack transparency, hindering user acceptance. Explainable AI (XAI) methods can help t...
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Open AccessCritical evaluation of molecular tumour board outcomes following 2 years of clinical practice in a Comprehensive Cancer Centre
Recently, molecular tumour boards (MTBs) have been integrated into the clinical routine. Since their benefit remains debated, we assessed MTB outcomes in the Comprehensive Cancer Center Ostbayern (CCCO) from 2...
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Article
Reciprocal interactions between innate immune cells and astrocytes facilitate neuroinflammation and brain metastasis via lipocalin-2
Brain metastasis still encompass very grim prognosis and therefore understanding the underlying mechanisms is an urgent need toward develo** better therapeutic strategies. We uncover the intricate interactio...
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Open AccessAuthor Correction: Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression
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Open AccessIncidence and Mortality of Malignant Melanoma in Relation to Dermatologist Density in Bavaria
Malignant melanoma is an aggressive skin tumor with a good prognosis when treated in an early tumor stage, but has a poor prognosis with distant metastases. The incidence of malignant melanoma has increased co...
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Open AccessHead and neck melanoma: outcome and predictors in a population-based cohort study
To evaluate predictive clinico-pathological characteristics on outcome in head and neck melanoma (HNM) in a population-based study with particular emphasis on the prognostic effect of sentinel lymph node biops...
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Open AccessAssociation between physical activity, grip strength and sedentary behaviour with incidence of malignant melanoma: results from the UK Biobank
Physical activity has been positively related to malignant melanoma. However, that association may be confounded by ultraviolet radiation (UV), a variable closely related to both outdoor physical activity and ...
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Article
Open AccessActivity of ipilimumab plus nivolumab in avelumab-refractory Merkel cell carcinoma
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine cutaneous malignancy with poor prognosis. In Europe, approved systemic therapies are limited to the PD-L1 inhibitor avelumab. For avelumab-re...
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Article
Open AccessPatterns of care and follow-up care of patients with uveal melanoma in German-speaking countries: a multinational survey of the German Dermatologic Cooperative Oncology Group (DeCOG)
Uveal melanoma (UM) is an orphan cancer of high unmet medical need. Current patterns of care and surveillance remain unclear as they are situated in an interdisciplinary setting.
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Article
Open AccessVirus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis
Treatment of advanced melanoma with combined PD-1/CTLA-4 blockade commonly causes serious immune-mediated complications. Here, we identify a subset of patients predisposed to immune checkpoint blockade-related...
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Article
Open AccessA Retrospective Chart Review Study of Real-World Use of Talimogene Laherparepvec in Unresectable Stage IIIB–IVM1a Melanoma in Four European Countries
Talimogene laherparepvec (T-VEC; IMLYGIC®, Amgen Inc.) is an oncolytic immunotherapy approved in Europe for the treatment of unresectable metastatic melanoma (stage IIIB–IVM1a). This study characterised real-worl...
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Article
Patients with BRAF-Mutant Advanced/Metastatic Melanoma: Original Research on the Treatment Reality in Germany and Austria in the Era of Choice
Cutaneous melanoma is one of the most aggressive forms of skin neoplasms and represents a major cause of neoplastic or cancer death in Europe. Without adequate therapy, the 5-year survival rate is 15% when the...
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Open AccessAuthor Correction: Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessIntegrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
Immune-checkpoint blockade (ICB) has demonstrated efficacy in many tumor types, but predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study, we analyzed a clinically annotate...
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Article
Combination of denosumab and immune checkpoint inhibition: experience in 29 patients with metastatic melanoma and bone metastases
PD-1 inhibition (PD-1i) is the standard of care in melanoma and other malignancies. In patients with bone metastases of solid tumors, the monoclonal antibody denosumab directed against RANKL is approved for th...
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Open AccessReal-World Use of Talimogene Laherparepvec in German Patients with Stage IIIB to IVM1a Melanoma: A Retrospective Chart Review and Physician Survey
Talimogene laherparepvec is a first-in-class oncolytic immunotherapy for intratumoral injection with proven efficacy and tolerability in patients with unresectable early metastatic melanoma (stage IIIB–IVM1a) ...
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Article
Studies on the mechanochemical Knoevenagel condensation of fluorinated benzaldehyde derivates
The mechanochemical Knoevenagel condensation of three fluorinated benzaldehyde derivates and malononitrile was investigated. The reactions were performed under solvent- and catalyst-free conditions and resulte...
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Article
Open AccessBRAF inhibition causes resilience of melanoma cell lines by inducing the secretion of FGF1
Approximately half of all melanoma patients harbour activating mutations in the serine/threonine kinase BRAF. This is the basis for one of the main treatment strategies for this tumor type, the targeted therap...
