-
Article
Open AccessPharmacokinetics of tenofovir alafenamide, emtricitabine, and dolutegravir in a patient on peritoneal dialysis
Peritoneal dialysis (PD) is an effective renal replacement modality in people with HIV (PWH) with end-stage kidney disease (ESKD), particularly those with residual kidney function. Data on pharmacokinetics (PK...
-
Article
Open AccessClinically relevant atovaquone-resistant human malaria parasites fail to transmit by mosquito
Long-acting injectable medications, such as atovaquone, offer the prospect of a “chemical vaccine” for malaria, combining drug efficacy with vaccine durability. However, selection and transmission of drug-resi...
-
Article
Fecal Coliform Bacterial Detection to Assess Enema Adherence in HIV Prevention Clinical Studies
Evaluating the efficacy of any HIV prevention strategy is dependent on ensuring and objectively monitoring adherence to the intervention. Medicated rectal enemas are a potential method for providing topical, e...
-
Article
Open AccessLong-acting injectable atovaquone nanomedicines for malaria prophylaxis
Chemoprophylaxis is currently the best available prevention from malaria, but its efficacy is compromised by non-adherence to medication. Here we develop a long-acting injectable formulation of atovaquone soli...
-
Protocol
Pharmacodynamics of Antimalarial Agents
Antimalarials were among the first, and today are among the most widely used, anti-infective agents. The fundamental pharmacodynamic endpoint for antimalarials is quite simple: elimination of this eukaryotic p...
-
Article
Open AccessAmerican ginseng (Panax quinquefolius) administration does not affect performance of the Roche COBAS Ampliprep/Taqman HIV-1 RNA assay
Previous data indicate that purified components of ginseng can inhibit HIV reverse transcriptase in vitro, suggesting that ginseng components in plasma may interfere with HIV-1 RNA detection assays.
