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Open AccessPermissive versus restrictive temperature thresholds in critically ill children with fever and infection: a multicentre randomized clinical pilot trial
Fever improves pathogen control at a significant metabolic cost. No randomized clinical trials (RCT) have compared fever treatment thresholds in critically ill children. We performed a pilot RCT to determine w...
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Article
Open AccessMortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS)
Sepsis is one of the main reasons for non-elective admission to pediatric intensive care units (PICUs), but little is known about determinants influencing outcome. We characterized children admitted with commu...
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Attitudes towards fever amongst UK paediatric intensive care staff
The role played by fever in the outcome of critical illness in children is unclear. This survey of medical and nursing staff in 35 paediatric intensive care units and transport teams in the United Kingdom and ...
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Mind over matter? Pain, withdrawal and sedation in paediatric critical care
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Visualizing secondary brain insults: does the emperor have new clothes?
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Tools for revealing uncomfortable truths? Measuring child-centred health-related quality of life after paediatric intensive care
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Open AccessOptimism and no longer foolishness? Haematology/oncology and the PICU
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Genetic polymorphisms in the endotoxin receptor may influence platelet count as part of the acute phase response in critically ill children
To determine if common polymorphisms in the endotoxin recognition complex influence the acute phase response as determined by the development of the systemic inflammatory response syndrome (SIRS) and platelet ...
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Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children
The D allele of the I/D polymorphism in the angiotensin-converting enzyme (ACE) gene has been associated with an increased risk of ARDS in critically ill adults and severity of bronchopulmonary dysplasia in pre-t...
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Mannose-binding lectin and pulmonary morbidity in premature infants