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  1. Article

    Open Access

    Target attainment of cefotaxime in critically ill children with meningococcal septic shock as a model for cefotaxime dosing in severe pediatric sepsis

    Reduced target attainment of β-lactam antibiotics is reported in critically ill patients. However, as target attainment of cefotaxime in severely ill pediatric sepsis patients may differ from adults due to age...

    Stan J. F. Hartman, Navin P. Boeddha… in European Journal of Clinical Microbiology … (2019)

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  2. Article

    Open Access

    Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS)

    Sepsis is one of the main reasons for non-elective admission to pediatric intensive care units (PICUs), but little is known about determinants influencing outcome. We characterized children admitted with commu...

    Navin P. Boeddha, Luregn J. Schlapbach, Gertjan J. Driessen… in Critical Care (2018)

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  3. Article

    Open Access

    Overview of 15-year severe combined immunodeficiency in the Netherlands: towards newborn blood spot screening

    Severe combined immune deficiency (SCID) is a fatal primary immunodeficiency usually presenting in the first months of life with (opportunistic) infections, diarrhea, and failure to thrive. Hematopoietic stem ...

    Anne P. J. de Pagter, Robbert G. M. Bredius… in European Journal of Pediatrics (2015)

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  4. No Access

    Article

    Measurement of Pneumococcal Polysaccharide Vaccine Responses for Immunodeficiency Diagnostics: Combined IgG Responses Compared to Serotype Specific IgG Responses

    Willemijn J. M. Janssen, Andries C. Bloem… in Journal of Clinical Immunology (2014)