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  1. No Access

    Article

    Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication

    The disialoganglioside GD2 is overexpressed on several solid tumors, and monoclonal antibodies targeting GD2 have substantially improved outcomes for children with high-risk neuroblastoma. However, approximate...

    Johanna Theruvath, Marie Menard, Benjamin A. H. Smith, Miles H. Linde… in Nature Medicine (2022)

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    Article

    Aged skeletal stem cells generate an inflammatory degenerative niche

    Loss of skeletal integrity during ageing and disease is associated with an imbalance in the opposing actions of osteoblasts and osteoclasts1. Here we show that intrinsic ageing of skeletal stem cells (SSCs)2 in m...

    Thomas H. Ambrosi, Owen Marecic, Adrian McArdle, Rahul Sinha, Gunsagar S. Gulati… in Nature (2021)

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    Article

    CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

    Ovarian cancer and triple-negative breast cancer are among the most lethal diseases affecting women, with few targeted therapies and high rates of metastasis. Cancer cells are capable of evading clearance by m...

    Amira A. Barkal, Rachel E. Brewer, Maxim Markovic, Mark Kowarsky, Sammy A. Barkal… in Nature (2019)

  4. No Access

    Article

    Isolation and functional assessment of mouse skeletal stem cell lineage

    A flow cytometry–based approach using eight surface markers is used to distinguish cells of the skeletal stem cell lineage. Renal subcapsular transplantation and in vitro colony-formation assays are also describe...

    Gunsagar S Gulati, Matthew P Murphy, Owen Marecic, Michael Lopez… in Nature Protocols (2018)