-
Article
Silencing of endogenous IGFBP-5 by micro RNA interference affects proliferation, apoptosis and differentiation of neuroblastoma cells
Signal transduction through the IGF axis is implicated in proliferation, differentiation and survival during development and adult life. The IGF axis includes the IGF binding proteins (IGFBPs) that bind IGFs w...
-
Article
Cyclin D1-dependent regulation of B-myb activity in early stages of neuroblastoma differentiation
Levels of the transcription factor B-myb must be down-regulated to allow terminal differentiation of neuroectodermal cells and yet its constitutive expression induces early markers of neural differentiation. T...
-
Article
Synthesis and properties of benzo [d,e]estra-1,3,5(10)-triene-3,17β-diol 17-acetate
A new pentacyclic analogue of estradiol, benzo[d, e]estradiol 17-acetate, has been prepared and investigated for its hormonal and antitumor activity. Unlike related testosterone derivatives, the new compound d...
-
Article
9α-fluoro-11β-hydroxybenzo [d, e] testosterone 17-acetate. A modified steroid highly active on DMBA-induced mammary tumors in rats
È stato preparato un nuovo analogo pentaciclico del testosterone e ne sono state saggiate le proprietà ormonali e l'attività nel test del tumore mammario indotto dal DMBA nel ratto. Il conposto ha dimostrato u...