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Article
Open AccessMeasurement of the double- \(\varvec{\beta }\) decay of \(\varvec{^{150}}\) Nd to the 0 \(\varvec{^+_1}\) excited state of \(\varvec{^{150}}\) Sm in NEMO-3
The NEMO-3 results for the double- \(\beta \) β decay of
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Article
Open AccessA Phase I/II Clinical Trial to evaluate the efficacy of baricitinib to prevent respiratory insufficiency progression in onco-hematological patients affected with COVID19: A structured summary of a study protocol for a randomised controlled trial
Baricitinib is supposed to have a double effect on SARS-CoV2 infection. Firstly, it reduces the inflammatory response through the inhibition of the Januse-Kinase signalling transducer and activator of transcri...
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Article
Open AccessUpdate of the recommendations for the determination of biomarkers in colorectal carcinoma: National Consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology
In this update of the consensus of the Spanish Society of Medical Oncology (Sociedad Española de Oncología Médica—SEOM) and the Spanish Society of Pathology (Sociedad Española de Anatomía Patológica—SEAP), adv...
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Article
Increased survival time or better quality of life? Trade-off between benefits and adverse events in the systemic treatment of cancer
Primary objective of the study was to assess the relative weighting between benefit in survival time (SV), benefit in quality of life (QoL) and willingness to experience adverse events (AEs), in patient prefer...
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Article
Open AccessDetailed studies of \(^{100}\) Mo two-neutrino double beta decay in NEMO-3
The full data set of the NEMO-3 experiment has been used to measure the half-life of the two-neutrino double beta decay of \(^{100}\) ...
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Article
Open AccessFinal results on \({}^\mathbf{82 }{\hbox {Se}}\) double beta decay to the ground state of \({}^\mathbf{82 }{\hbox {Kr}}\) from the NEMO-3 experiment
Using data from the NEMO-3 experiment, we have measured the two-neutrino double beta decay ( \(2\nu \beta \beta \) ...
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Article
Translational research in neuroendocrine tumors: pitfalls and opportunities
Interest in research on neuroendocrine tumors (NETs) has grown in the past 10 years, coinciding with improvements in our understanding of the molecular pathogenesis of NETs. In addition, NETs have become one o...
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Article
Open AccessGate-Controlled WSe2 Transistors Using a Buried Triple-Gate Structure
In the present paper, we show tungsten diselenide (WSe2) devices that can be tuned to operate as n-type and p-type field-effect transistors (FETs) as well as band-to-band tunnel transistors on the same flake. Sou...
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Article
Exact Energy Computation of the One Component Plasma on a Sphere for Even Values of the Coupling Parameter
The two dimensional one component plasma 2dOCP is a classical system consisting of N identical particles with the same charge q confined in a two dimensional surface with a neutralizing background. The Boltzmann ...
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Article
Recommendations in the management of epithelial appendiceal neoplasms and peritoneal dissemination from mucinous tumours (pseudomyxoma peritonei)
The epithelial appendiceal neoplasms are uncommon and are usually detected as an unexpected surgical finding. The general surgeon should be aware of the diversity of its clinical manifestations and biological ...
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Article
Open AccessSEOM clinical guidelines for diagnosis and treatment of metastatic colorectal cancer 2015
Colorectal cancer (CRC) is the second leading cause of cancer dead in Spain. About half the patients will eventually develop distant metastases. However, as treatment options are expanding, prognosis has stead...
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Article
Updated guidelines for biomarker testing in colorectal carcinoma: a national consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology
Publication of this consensus statement is a joint initiative of the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM), intended to revise and update the diagnostic and tre...
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Article
Pancreatic NETs: where do we stand now?
The systemic management of patients with pancreatic neuroendocrine tumors includes chemotherapy and targeted agents such as everolimus and sunitinib. Which treatment to favor in a particular patient is not kno...
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Article
Cytoreductive surgery and intraperitoneal chemotherapy for treatment of peritoneal carcinomatosis from colorectal origin
Peritoneal carcinomatosis (PC) is a common form of tumour metastasis stemming from gastrointestinal and colorectal cancers. For a long time, PC has been considered a terminal clinical condition treated only wi...
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Article
Phase I study of weekly kahalalide F as prolonged infusion in patients with advanced solid tumors
Kahalalide F (KF) is a dehydroaminobutyric acid-containing peptide from marine origin with activity against several human malignant cell lines. This dose-escalating phase I clinical trial evaluated the maximum...
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Article
A phase I, dose-finding study of sunitinib combined with cisplatin and 5-fluorouracil in patients with advanced gastric cancer
Background This phase I, open-label, dose-escalation study examined the safety, maximum tolerated dose (MTD), and pharmacokinetics of sunitinib plus chemotherapy in patients with advanced gastric...
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Article
Phase I dose-escalating study of ES-285 given as a three-hour intravenous infusion every three weeks in patients with advanced malignant solid tumors
Background ES-285 (spisulosine) is a novel compound derived from the marine mollusk Spisula polynoma with evidence of preclinical antitumor activity. This phase I clinical trial was designed to i...
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Article
A phase I and pharmacokinetic study of elisidepsin (PM02734) in patients with advanced solid tumors
To determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), and recommended phase II dose (RD) of elisidepsin.
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Article
Mineralization of Triadimefon Fungicide in Water by Electro-Fenton and Photo Electro-Fenton
The complete mineralization of the conazole fungicide triadimefon in water at pH 3 using electrochemical advanced oxidation processes, electro-Fenton and photo electro-Fenton, was achieved. The electrochemical...
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Article
Polymorphism Thr160Thr in SRD5A1, involved in the progesterone metabolism, modifies postmenopausal breast cancer risk associated with menopausal hormone therapy
Menopausal hormone therapy (MHT) is associated with an increased breast cancer risk in postmenopausal women, with combined estrogen–progestagen therapy posing a greater risk than estrogen monotherapy. However,...
