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  1. Article

    Open Access

    Assessing cross-resistance within the pyrethroids in terms of their interactions with key cytochrome P450 enzymes and resistance in vector populations

    It is important to understand whether the potential impact of pyrethroid resistance on malaria control can be mitigated by switching between different pyrethroids or whether cross-resistance within this insect...

    C. L. Moyes, R. S. Lees, C. Yunta, K. J. Walker, K. Hemmings… in Parasites & Vectors (2021)

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  2. No Access

    Chapter

    MED-PED: An Integrated Genetic Strategy for Preventing Early Deaths

    New opportunities are emerging for preventing the consequences of serious diseases because of the discovery of causal mutations in specific gene loci. MED PED is an international collaboration to Make Early Diagn...

    R. R. Williams, I. Hamilton-Craig… in Genetic Approaches to Noncommunicable Dise… (1996)

  3. No Access

    Chapter

    Peptides in Biomedical Sciences: Principles and Practice

    This review will discuss the evolution of radiopharmaceutical carriers and how peptides provide a new opportunity to develop highly specific carriers with desirable properties. The technical challenges in deve...

    R. T. Dean, J. L. -James, R. S. Lees, A. M. Lees… in Radiolabeled Blood Elements (1994)

  4. No Access

    Article

    Phospholipase A2-catalysed modification of plasma low density lipoproteins caused reduction of hypercholesterolemic rabbit plasma cholesterolin vivo

    Phospholipase A2 (PLA2) hydrolyses certain phospholipids of low density lipoproteins. PLA2-treated LDL is known to be rapidly cleared from plasma. A prototype plasma filter containing immobilizedCrotalus atrox PL...

    R. Labeque, B. M. Clark, J. Ferreira… in Journal of Materials Science: Materials in… (1992)

  5. No Access

    Chapter and Conference Paper

    Effects of Sitosterol Therapy on Plasma Lipid and Lipoprotein Concentrations

    The ideal drug for the treatment of hypercholesterolemia should be effective, free of subjective side-effects and of objective toxicity. The cholesterol analog, beta-sitosterol (Fig. 1), comes close to that id...

    R. S. Lees, Ann M. Lees in Lipoprotein Metabolism (1976)

  6. No Access

    Chapter and Conference Paper

    Workshop: Dietary Management of Hyperlipoproteinemias

    Hyperlipidemias (hyperlipoproteinemias) have become one of the commonest metabolic syndromes. The incidence of hyperlipidemias in the general population, on the basis of published data (Schlierf et al., 1972; ...

    R. Furman, G. Schlierf, Y. Goto, S. Grundy, G. Hartmann, R. S. Lees… in Atherosclerosis III (1974)

  7. No Access

    Chapter and Conference Paper

    Workshop: Management of Hyperlipoproteinemias with Non-Absorbable Drugs

    The workshop in the management of atherosclerosis was concerned with non-absorb-able drugs. These agents act within the intestinal lumen interfering with cholesterol and bile acid absorption. The resulting enh...

    F. A. Gries, T. Miettinen, G. Crepaldi, S. M. Grundy, K. J. Hahn… in Atherosclerosis III (1974)