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Article
Evaluation of DNA damage by alkaline elution technique after inhalation exposure of rats and mice to 1,3-butadiene
The alkaline filter elution technique was used to evaluate single strand breaks (SSB), DNA-DNA (DDCL) and DNA-protein cross-links (DPCL) in liver and lung of male rats (Sprague-Dawley) and male mice (B6C3F1) a...
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Chapter and Conference Paper
Acute Experimental Exposures to Acetone and Ethyl Acetate
Among the volatile organic solvents, acetone (AC) 54% and ethyl acetate (EA) 39% were found as major components after toluene 69% in 101 glues analyzed in Germany (Auffarth and Häger 1989). Pulmonary absorptio...
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Article
Formation and repair of DNA lesions in kidneys of male mice after acute exposure to methyl chloride
The time-course of DNA lesions (DNA-protein cross-links, single-strand breaks) induced by high concentrations of methyl chloride (1000 ppm) was measured in renal tissue of male mice by means of the alkaline el...
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Chapter and Conference Paper
Species Differences in DNA Damage by Butadiene: Role of Diepoxybutane
In microsomal incubates 1,3-butadiene (BD) is metabolized by cytochrome P- 450 to its epoxide 1,2-epoxybutene (EB). Further metabolic transformation of the epoxide intermediate by epoxide hydrolase and/or mono...
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Chapter and Conference Paper
Detection of DNA-Protein Crosslinks in the Kidney of Male B6C3F1 Mice after Exposure to Methyl Chloride
Long-term exposure (two years) of male and female B6C3F1 mice to high concentrations (1000 ppm) of methyl chloride resulted in an increased incidence of renal tumours in males only (Batelle Columbus Laboratori...
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Chapter and Conference Paper
Species Differences in Pharmacokinetics, Metabolism, and DNA Binding of Inhaled 1,3-Butadiene
1,3-Butadiene, a major component in synthetic rubber and adiponitrile manufacture, has been found to produce cancer at multiple anatomic sites in two species of experimental animals. In an inhalation bioassay ...
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Article
Effect of cotton dust extract on circulatory parameters in protracted anaphylactic shock of sensitized rats
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Article
A new approach to the direct determination of histamine in organic matrices
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Article
Vergleich verschiedener Methoden zur Bestimmung von Tryptophan in Proteinen
Attempts have been made to establish suitable conditions for the liberation of trytophan from proteins, particularly legumeproteins. The hydrolyses were carried out With 3.5% HClO4, 4N-Ba(OH)2, 4N-KOH and papain....
