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Open AccessAssociation between central blood pressure, arterial stiffness, and mild cognitive impairment
To determine the relationship between central blood pressure (CBP) indices and mild cognitive impairment (MCI) in adults over the age of 50.
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Article
Women with severe obesity and relatively low bone mineral density have increased fracture risk
Among women with obesity, those with the lowest bone density have the highest fracture risk. The types of fractures include any fracture, fragility-type fractures (vertebra, hip, upper arm, forearm, and lower ...
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The obesity paradox in heart failure patients with preserved versus reduced ejection fraction: a meta-analysis of individual patient data
In heart failure (HF), obesity, defined as body mass index (BMI) ⩾30 kg m−2, is paradoxically associated with higher survival rates compared with normal-weight patients (the ‘obesity paradox’). We sought to deter...
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Multicomponent, home-based resistance training for obese adults with type 2 diabetes: a randomized controlled trial
To investigate whether a home-based resistance training (RT) program that supplied high-quality equipment and qualified exercise specialists could provide benefits to obese patients with type 2 diabetes.
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Association between obesity and health-related quality of life in patients with coronary artery disease
In patients with coronary artery disease (CAD), obesity is paradoxically associated with better survival (the ‘obesity paradox’). Our objective was to determine whether this counterintuitive relationship exten...
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Long-term persistence with orlistat and sibutramine in a population-based cohort
Orlistat and sibutramine are widely prescribed antiobesity agents that are approved for 2 years of continuous use. Previous 1–4-year randomized, placebo-controlled trials of these drugs have reported average w...
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Medicijnen om af te vallen
Achtergrond Overgewicht en obesitas nemen wereldwijd endemische vormen aan. Een relatief hoog-energetisch voedingspatroon en een zittend bestaan zijn de twee belangrijkste oorzaken van een te hoog lichaamsgewicht...
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Long-term pharmacotherapy for overweight and obesity: a systematic review and meta-analysis of randomized controlled trials
CONTEXT: Safe and effective strategies to curb rising obesity prevalence rates are urgently needed and medications may play a more prominent role in future therapeutic regimens.