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  1. No Access

    Chapter and Conference Paper

    Species Differences in Pharmacokinetics, Metabolism, and DNA Binding of Inhaled 1,3-Butadiene

    1,3-Butadiene, a major component in synthetic rubber and adiponitrile manufacture, has been found to produce cancer at multiple anatomic sites in two species of experimental animals. In an inhalation bioassay ...

    R. J. Laib, S. Deutschmann, B. Jelitto, R. R. Vangala… in Assessment of Inhalation Hazards (1989)

  2. No Access

    Article

    DNA adducts of halogenated hydrocarbons

    Although formation of DNA adducts has been postulated for several halomethanes, no chemical identification of such adducts has been performed so far. There is, however, evidence that methyl chloride does not a...

    H. M. Bolt, R. J. Laib, H. Peter… in Journal of Cancer Research and Clinical On… (1986)

  3. No Access

    Article

    Vinyl chloride and trichloroethylene: Comparison of alkylating effects of metabolites and induction of preneoplastic enzyme deficiencies in rat liver

    [1,2-14C] Vinyl chloride and [1,2-14C] trichloroethylene were incubated with rat liver microsomes, NADPH and RNA (from yeast). Whereas trichloroethylene metabolites were irreversibly bound to proteins in microsom...

    R. J. Laib, G. Stöckle, H. M. Bolt, W. Kunz in Journal of Cancer Research and Clinical On… (1979)