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Article
Erratum: VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis
Correction to: Genes and Immunity (2017) 18, 48–56; doi:10.1038/gene.2016.49; published online 5 January 2017 Since the publication of this article the authors found that there were errors in titles of Tables ...
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Article
VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis
Rheumatoid arthritis (RA) patients can be stratified into two subgroups defined by the presence or absence of antibodies against citrullinated circular peptides (anti-CCP) with most of the genetic association ...
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Article
Finemap** of the arthritis QTL Pia7 reveals co-localization with Oia2 and the APLEC locus
In this study, we sought to determine the effect of the quantitative trait locus Pia7 on arthritis severity. The regulatory locus derived from the arthritis-resistant E3 rat strain was introgressed into the arthr...
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Article
Cell-specific and efficient expression in mouse and human B cells by a novel hybrid immunoglobulin promoter in a lentiviral vector
The expression of genes specifically in B cells is of great interest in both experimental immunology as well as in future clinical gene therapy. We have constructed a novel enhanced B cell-specific promoter (I...
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Article
Gene expression profiling of arthritis using a QTL chip reveals a complex gene regulation of the Cia5 region in mice
One of the major quantitative trait loci (QTLs) associated with arthritis in crosses between B10.RIII and RIIIS/J mice is the Cia5 on chromosome 3. Early in the congenic map** process it was clear that the locu...
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Article
Identification of epistasis through a partial advanced intercross reveals three arthritis loci within the Cia5 QTL in mice
Identification of genes controlling complex diseases has proven to be difficult; however, animal models may pave the way to determine how low penetrant genes interact to promote disease development. We have di...