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Article
Open AccessLactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression
Abundant macrophage infiltration and altered tumor metabolism are two key hallmarks of glioblastoma. By screening a cluster of metabolic small-molecule compounds, we show that inhibiting glioblastoma cell glyc...
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Article
Inherent genome instability underlies trisomy 21-associated myeloid malignancies
Constitutional trisomy 21 (T21) is a state of aneuploidy associated with high incidence of childhood acute myeloid leukemia (AML). T21-associated AML is preceded by transient abnormal myelopoiesis (TAM), which...
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Article
RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia
Many inherited bone marrow failure syndromes (IBMFSs) present a high risk of transformation to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). During transformation of IBMFSs, hematopoietic st...
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Article
Induced pluripotent stem cells in disease modelling and drug discovery
The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked widespread enthusiasm for the development of new models of human disease, enhanced platforms for drug discovery and more wides...
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Article
Open AccessReconstruction of complex single-cell trajectories using CellRouter
A better understanding of the cell-fate transitions that occur in complex cellular ecosystems in normal development and disease could inform cell engineering efforts and lead to improved therapies. However, a ...
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Article
Haematopoietic stem and progenitor cells from human pluripotent stem cells
A variety of tissue lineages can be differentiated from pluripotent stem cells by mimicking embryonic development through stepwise exposure to morphogens, or by conversion of one differentiated cell type into ...
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Article
Valine starvation leads to a hungry niche
The haematopoietic stem cells that rejuvenate blood depend on a dietary source of the amino acid valine — a finding that has been exploited to reduce the toxicity of bone-marrow transplantation in mice.
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Article
Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer
The zinc-finger transcription factor Snail1 is inappropriately expressed in breast cancer and associated with poor prognosis. While interrogating human databases, we uncovered marked decreases in relapse-free ...
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Article
Erratum: Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease.
Nat. Med. 21, 989–997 (2015); published online 03 August 2015; corrected after print 4 September 2015 In the version of this article initially published, the word 'genetically' was added by the editor to the p...
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Article
Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease
During renal fibrosis, epithelial cells undergo a partial epithelial-to-mesenchymal transition that can be targeted to reverse established disease.
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Article
A Snail1/Notch1 signalling axis controls embryonic vascular development
Notch1-Delta-like 4 (Dll4) signalling controls vascular development by regulating endothelial cell (EC) targets that modulate vessel wall remodelling and arterial–venous specification. The molecular effectors ...
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Article
Grain boundary segregation and grain growth inhibition in silicon iron: The effect of boron and nitrogen
The degree of grain growth inhibition in iron-3.1 pct silicon alloys with small additions of boron, nitrogen and sulfur has been observed to correlate strongly with the degree of nitrogen segregation to the gr...
