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  1. Article

    Open Access

    Decoding the pathogenesis of Diamond–Blackfan anemia using single-cell RNA-seq

    Ribosomal protein dysfunction causes diverse human diseases, including Diamond–Blackfan anemia (DBA). Despite the universal need for ribosomes in all cell types, the mechanisms underlying ribosomopathies, whic...

    Bingrui Wang, Chenchen Wang, Yang Wan, Jie Gao, Yige Ma, Yingnan Zhang… in Cell Discovery (2022)

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    Article

    A Snail1/Notch1 signalling axis controls embryonic vascular development

    Notch1-Delta-like 4 (Dll4) signalling controls vascular development by regulating endothelial cell (EC) targets that modulate vessel wall remodelling and arterial–venous specification. The molecular effectors ...

    Zhao-Qiu Wu, R. Grant Rowe, Kim-Chew Lim, Yongshun Lin… in Nature Communications (2014)

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    Article

    Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system

    Mouse embryos deficient in Gata3 die by 11 days post coitum (d.p.c.) from pathology of undetermined origin1. We recently showed that Gata3-directed lacZ expression of a 625-kb Gata3 YAC transgene in mice mimics e...

    Kim-Chew Lim, Ganesh Lakshmanan, Susan E. Crawford, Yi Gu… in Nature Genetics (2000)