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Article
Commentary on: “Stereotyped activities produced by amphetamine in several animal species and man.” Psychopharmacologia (1967) 11:300–310
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Chapter and Conference Paper
On the State of Knowledge in Neurobiological Psychiatry
Our present knowledge of neurobiological mechanisms in psychosomatic disorders or in mental disturbances connected with physical illness is practically nil. This reflects the state of knowledge in biological p...
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Chapter and Conference Paper
On Current Research in Affective Disorders
To give a short review of all the excellent papers of the current research in affective disorders in this volume is not an easy task. A lot of new data have emerged since I gave a similar review 3 years ago (Fog ...
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Chapter and Conference Paper
The Effect of Dopamine Antagonists in Spontaneous and Tardive Dyskinesia
Dopamine antagonists are effective in suppressing hyperkinetic symptoms in patients with tardive dyskinesia, spontaneous oral dyskinesia, Huntington’s chorea, and Gilles de la Tourette’s syndrome. These neurol...
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Chapter
Neuroleptic-induced ‘tardive Tourrette’s syndrome’ and neurotoxicity
Neurological side effects have been associated with neuroleptic drugs since these drugs were introduced in the treatment of psychiatric disorders. Acute dystonia and parkinsonism may be seen in the initial pha...
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Chapter
Amphetamines and psychosis
At the present stage of knowledge it seems reasonable to assume that every normal thought process or normal behaviour has one neuro-biological correlate, and that every abnormal form of function—even if induce...
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Chapter
Theoretical and Clinical Aspects of the Tourette Syndrome (Chronic Multiple Tic)
In three schizophrenic patients long-term neuroleptic treatment induced Tourette-like symptoms. There seems to be a partial overlap in the pathogenesis of Tourette Syndrome and tardive dyskinesia.
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Chapter
Stereotyped Behavior and Its Relevance for Testing Neuroleptics
During the early Sixties it became clear that the characteristic clinical effects of neuroleptics (antimanic, antischizophrenic, neurologic) correlated with their ability to antagonize stereotypies elicited in...
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Article
Extrapyramidal reactions and amine metabolites in cerebrospinal fluid during haloperidol and clozapine treatment of schizophrenic patients
8 male schizophrenic patients participated in a double-blind, cross over study of the extrapyramidal side-effects of haloperidol and clozapine (acute dystonia, Parkinsonism and tardive dyskinesia), together wi...
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Chapter
Catecholamines in Activation, Stereotypy, and Level of Mood
Studies of the effects of psychoactive drugs have contributed much to the present knowledge of the role of catecholamines in behavioral physiology. Since drugs are never completely specific, i.e., no drug acts...
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Article
Short-term effect of perphenazine enanthate on the rat brain
Having previously demonstrated that there is an approximately 20% loss of nerve cells in the basal ganglia (but no loss in the cortex) of rats following the administration of perphenazine enanthate for 12 mont...
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Article
The long-term effect of perphenazine enanthate on the rat brain. Some metabolic and anatomical observations
Perphenazine enanthate 3.4 mg/kg per injection, was administered subcutaneously to rats every second week over a period of a year, a total of 31 mg per animal being given. The animals were observed weekly and ...
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Article
Intrastriatal injection of quaternary butyrophenones and oxypertine: Neuroleptic effect in rats
Bilateral intrastriatal microinjections in rat brains of quaternary neuroleptic drugs of the butyrophenone type (haloperidol, benperidol, floropipamide) and the indole type (oxypertine) antagonize amphetamine-...
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Article
Lesions in corpus striatum and cortex of rat brains and the effect on pharmacologically induced stereotyped, aggressive and cataleptic behaviour
Large bilateral lesions affecting 30–90% of the corpus striatum inhibit stereotyped behaviour in rats injected subcutaneously with amphetamine, but do not prevent rage reactions induced by injection of a monoa...
