Abstract
In three schizophrenic patients long-term neuroleptic treatment induced Tourette-like symptoms. There seems to be a partial overlap in the pathogenesis of Tourette Syndrome and tardive dyskinesia.
In five Tourette patients treatment with pimozide was very effective inducing only few side-effects. Long-term neuroleptic treatment may, however, aggravate the symptoms in the long run.
A eombination treatment with tetrabenazine and pimozide is suggested.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Butler, I. J., Koslow, S. H., Seifert, W. E. Biogenic aminemetabolism in Tourette Syndrome. Ann. Neurol. 6 37–39 (1979).
Brunn, R. D., Shapiro, A. K A followup of 7 patients with Gilles de la Tourette Syndrome. Am. J. Psychiatry 133, 944–947 (1976).
Christensen, A. V., Meiler, N. L Dopaminergic supersensitivity: Influence of dopamine agonists, cholinergics, anticholinergics and drugs used for the treatment of tardive dyskinesia. Psychopharmacology62 111–116 (1979).
Fog, R., Pakkenberg, H.: Combined nitoman-pimozide treatment of Huntington’s chorea and other hyperkinetic syndromes. Acta neurol. scand. 46 249–251 (1970).
Fog, R., Pakkenberg, H.Combination treatment of hyperkinetic syndromes with tetrabenazine and pimozide. In: Tardive Dyskinesia Davis, J. M., Fann, W. E., Smith, R. C., eds.). New York: Spectrum Publications. 1979, in press.
Gerlach J Tardive dyskinesia. Dan. Med. Bull. 26209–245 (1979).
Gibson, A.: A comparison of different neuroleptic drugs and different ways of using neuroleptic drugs in the treatment of early tardive dyskinesia. In: Phenothiazines and Structurally Related Drugs. Basic and Clinical Studies Usdin, E., Eckert, H., Forrest, J., eds.). New York: Elsevier North-Holland. 1979 (in press)
Pakkenberg, H., Fog, R Spontaneous oral dyskinesia. Results of treatment with tetrabenazine, pimozide, or both. Arch. Neurol. 31, 352–353 (1974).
Pakkenberg, H., Fog, R., Nilakantan, B The long-term effect of Perphenazine enanthate on the rat brain. Some metabolic and anatomical observations. Psychopharmacologia (Berl.) 29, 329–336 (1973).
Snyder, S. H., Taylor, K. M., Coyle,J. T., The role of brain dopamine in behavioral regulation and the actions of psychotropic drugs. Am. J. Psychiatry 127 199–207 (1970).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Springer-Verlag
About this chapter
Cite this chapter
Fog, R., Pakkenberg, H. (1980). Theoretical and Clinical Aspects of the Tourette Syndrome (Chronic Multiple Tic). In: Carlsson, A., Jellinger, K., Riederer, P. (eds) Current Topics in Extrapyramidal Disorders. Journal of Neural Transmission, vol 16. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8582-7_24
Download citation
DOI: https://doi.org/10.1007/978-3-7091-8582-7_24
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-8584-1
Online ISBN: 978-3-7091-8582-7
eBook Packages: Springer Book Archive