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Article
Open AccessThe microstructure in the placenta is influenced by the functional diversity of HLA-G allelic variants
The main expression sites of HLA-G are human extravillous trophoblast cells. The interaction of HLA-G with uterine NK cells promotes their maturation and differentiation into decidual NK (dNK) cells. dNK cells...
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Article
Open AccessLentivirus-induced ‘Smart’ dendritic cells: Pharmacodynamics and GMP-compliant production for immunotherapy against TRP2-positive melanoma
Monocyte-derived conventional dendritic cells (ConvDCs) loaded with melanoma antigens showed modest responses in clinical trials. Efficacy studies were hampered by difficulties in ConvDC manufacturing and low ...
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Chapter
Antigen-Antikörper-Reaktion: Grundlagen serologischer Methoden
Der Nachweis von Antigenen oder Serumantikörpern spielt in der medizinischen Diagnostik eine bedeutende Rolle.
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Article
Open AccessHeat Shock Protein 70 (HSP70) induces cytotoxicity of T-helper cells
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Article
Open AccessHuman calreticulin can act as adjuvant in the maturation of antigen presenting cells
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Article
Open AccessNKG2A silencing in effector cells to improve effectivity of cell based therapeutics
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Article
Allogeneic stem cell transplantation from related and unrelated donors for aplastic anaemia in adults—a single-centre experience
Aplastic anaemia (AA) is a rare bone marrow failure syndrome treated either by immunosuppressive therapy or allogeneic stem cell transplantation (SCT). At present, no randomised clinical trials evaluating both...
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Article
Reply to the letter by Shaw et al
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Article
A comparative study of adverse reactions occurring after administration of glycosylated granulocyte colony stimulating factor and/or dexamethasone for mobilization of neutrophils in healthy donors
Both granulocyte colony-stimulating factor (G-CSF) and dexamethasone (DXM) are used for neutrophil (PMN) mobilization and collection. This prospective study was aimed to evaluate and compare the rate, severity...
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Article
Presentation assessment of minor histocompatibility antigens by predictive proteasomal cleavage analysis
Minor histocompatibility peptides (mHps) derived from polymorphic segments of endogenous proteins are thought to be targets for graft-versus-host and graft-versus-leukemia reactions after HLA-identical stem ce...
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Article
HistoCheck: rating of HLA class I and II mismatches by an internet-based software tool
HLA polymorphism is a major barrier for hematopoietic stem cell and solid organ transplantation. To estimate the allogeneic potential between HLA-mismatched stem cell donor/recipient pairs, we recently propose...
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Article
The nature of introns 4–6 suggests reduced lineage specificity in HLA-B alleles
For most HLA-B alleles, coding sequences of the 3′ part of the genes still need to be determined, and sequences of the 3′ noncoding regions have yet to be studied systematically. In this study, we have determi...
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Article
Second German consensus on immunogenetic donor search for allotransplantation of hematopoietic stem cells
The present paper summarizes the results of the second German consensus meeting on immunogenetic donor search for allotransplantation of hematopoietic stem cells held in Essen in November 1999 under the auspi...
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Article
Treatment of relapse after allogeneic bone marrow transplantation with unmanipulated G-CSF-mobilized peripheral blood stem cell preparation
Donor lymphocyte infusions (DLI) are an effective treatment of leukemia relapse after allogeneic bone marrow transplantation. Undesired side-effects are the development of graft-versus-host disease (GVHD) and ...
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Chapter and Conference Paper
Einfluß von Spender/Empfänger HLA-B Übereinstimmungen auf das Transplantatüberleben bei lebertransplantierten Patienten mit HBV- Zirrhose
Der Verlauf von Patienten, die wegen terminaler Leberzirrhose auf dem Boden von Viruserkrankungen orthotop lebertransplantiert worden sind, wird oft durch Reinfektionen des Transplantates mit dem Virus kompliz...
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Chapter
New HLA Ty** Methods
The human major histocompatibility complex (MHC) was discovered during studies initiated by J. Dausset, R. Payne and J. J. van Rood describing a genetically inherited system of alloantigens [1–3]. Initially hi...
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Article
German consensus on immunogenetic donor search for transplantation of allogeneic bone marrow and peripheral blood stem cells
In Germany allotransplantation of bone marrow or peripheral blood stem cells is presently performed by 34 different teams operating more or less independently. Thus, strategies of immunogenetic donor search, u...