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  1. No Access

    Article

    Assessing the contribution of the chemical exposome to neurodegenerative disease

    Over the past few decades, numerous environmental chemicals from solvents to pesticides have been suggested to be involved in the development and progression of neurodegenerative diseases. Most of the evidence...

    S. Lefèvre-Arbogast, J. Chaker, F. Mercier, R. Barouki, X. Coumoul… in Nature Neuroscience (2024)

  2. No Access

    Article

    The aryl hydrocarbon receptor regulates focal adhesion sites through a non-genomic FAK/Src pathway

    The aryl hydrocarbon receptor (AhR) is commonly described as a transcription factor, which regulates xenobiotic-metabolizing enzymes. Recent studies have suggested that the binding of ligands to the AhR also a...

    C Tomkiewicz, L Herry, L-C Bui, C Métayer, M Bourdeloux, R Barouki, X Coumoul in Oncogene (2013)

  3. No Access

    Chapter

    Le tissu adipeux : stockage, source et cible des polluants

    Initialement considéré comme un tissu de «stockage», relativement passif, cantonné aux fonctions physiques et énergétiques, le tissu adipeux (TA) s’est vu progressivement attribuer de nouvelles fonctions physi...

    R. Barouki, K. Clément in Physiologie et physiopathologie du tissu adipeux (2013)

  4. No Access

    Article

    ≪ 3es Rencontres médecins-chirurgiens ≫ sur la chirurgie de l’obésité

    Le tissu adipeux est capable de stocker certains polluants organiques mais aussi de libérer ces derniers, tout particulièrement en cas d’amaigrissement important ou prolongé. Les conséquences défavorables ou, ...

    R. Barouki, K. Clément in Obésité (2009)

  5. No Access

    Article

    Nedd9/Hef1/Cas-L mediates the effects of environmental pollutants on cell migration and plasticity

    Aryl hydrocarbon receptor (AhR), or dioxin receptor, is a transcription factor that induces adaptive metabolic pathways in response to environmental pollutants. Recently, other pathways were found to be altere...

    L -C Bui, C Tomkiewicz, A Chevallier, S Pierre, A -S Bats, S Mota, J Raingeaud… in Oncogene (2009)

  6. No Access

    Article

    Activation of the dioxin/aryl hydrocarbon receptor (AhR) modulates cell plasticity through a JNK-dependent mechanism

    Environmental chemicals such as dioxin adversely affect immune, neurological and reproductive functions and have been implicated in cancer development. However, the mechanisms responsible for dioxin toxicity a...

    M Diry, C Tomkiewicz, C Koehle, X Coumoul, K Walter Bock, R Barouki, C Transy in Oncogene (2006)

  7. No Access

    Chapter and Conference Paper

    Cytosolic aspartate aminotransferase : tissue-specific hormonal regulation of a housekee** gene promoter

    The cytosolic aspartate aminotransferase gene is an unusual housekee** gene that is hormonally regulated in a highly tissue-specific manner. The cAspAT enzyme is involved in several cellular metabolic pathwa...

    R. Barouki, M. Garlatti, S. Feilleux-Duché… in Biochemistry of Vitamin B6 and PQQ (1994)

  8. No Access

    Article

    Different chromosomal localization of two adenylyl cyclase genes expressed in human brain

    Recently, we characterized a cDNA clone that encodes a human brain adenylyl cyclase (HBAC1). In the present study, we identified a second population of mRNA suspected to encode a new brain adenylyl cyclase (HB...

    D. Stengel, J. Parma, M. -H. Gannagé, N. Roeckel, M. -G. Mattei… in Human Genetics (1992)

  9. No Access

    Article

    Chromosomal localization of human aspartate aminotransferase genes by in situ hybridization

    The localization of the human genes for cytosolic and mitochondrial aspartate aminotransferase (AspAT) has been determined by chromosomal in situ hybridization with specific human cDNA probes previously charac...

    S. Pol, B. Bousquet-Lemercier, M. Pavé-Preux, F. Bulle, E. Passage… in Human Genetics (1989)