20 Result(s)

Article

In vivo imaging of specific drug–target binding at subcellular resolution

The possibility of measuring binding of small-molecule drugs to desired targets in live cells could provide a better understanding of drug action. However, current approaches mostly yield static data, require ...

J. M. Dubach, C. Vinegoni, R. Mazitschek, P. Fumene Feruglio… in Nature Communications (2014)

Article

Epigenetic memory in induced pluripotent stem cells

Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through different mechanisms...

K. Kim, A. Doi, B. Wen, K. Ng, R. Zhao, P. Cahan, J. Kim, M. J. Aryee, H. Ji… in Nature (2010)

Article

Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors

Novel therapeutic agents combined with innovative modes of delivery and non-invasive imaging of drug delivery, pharmacokinetics and efficacy are crucial in develo** effective clinical anticancer therapies. I...

M van Eekelen, L S Sasportas, R Kasmieh, S Yip, J-L Figueiredo, D N Louis… in Oncogene (2010)

Article

Von vulnerablem Plaque bis Infarktheilung – neue Perspektiven in der Kardiologie mit molekularer Bildgebung

Fortschritte in Bildgebungstechnik, Kontrastmittelchemie, Molekularbiologie und Nanotechnologie lassen uns zu Zeitzeugen eines Paradigmenwechsels in der kardiovaskulären Diagnostik werden. Anstatt wie bisher d...

M. Nahrendorf, R. Weissleder in Der Radiologe (2007)

Chapter and Conference Paper

Magnetic Resonance Signal Amplification Probes

A. A. Bogdanov Jr., J. W. Chen, H. W. Kang, R. Weissleder in Molecular Imaging (2005)

Article

Molecular imaging of gene therapy for cancer

Gene therapy of cancer has been one of the most exciting and elusive areas of scientific and clinical research in the past decade. One of the most critical issues for ensuring success of this therapy is the de...

K Shah, A Jacobs, X O Breakefield, R Weissleder in Gene Therapy (2004)

Article

Targeting of MPEG-protected polyamino acid carrier to human E-selectin in vitro

 Targeted diagnostic agents are expected to have a significant impact in molecular imaging of cell-surface associated markers of proliferation, inflammation and angiogenesis. In this communication, we describe...

H. W. Kang, R. Weissleder, A. Bogdanov, Jr. in Amino Acids (2002)

Article

DNA binding chelates for nonviral gene delivery imaging

Noninvasive in vivo monitoring of gene delivery would provide a critically important information regarding the spatial distribution, local concentration, kinetics of removal and/or biodegradation of the expres...

A Bogdanov Jr, C-H Tung, S Bredow, R Weissleder in Gene Therapy (2001)

Article

Experimentelle Radiologie in den USA

R. Weissleder in Der Radiologe (2001)

Article

Molekulare Bildgebung in der Magnetresonanztomographie und der Nuklearmedizin

D. Högemann, J.P. Basilion, R. Weissleder in Der Radiologe (2001)

Article

Fortschritte in der optischen Bildgebung

C. Bremer, V. Ntziachristos, U. Mahmood, C.-H. Tung, R. Weissleder in Der Radiologe (2001)

Article

Experimentelle und klinische Ansätze zur Lymphknotenbildgebung

P. Wunderbaldinger, R. Weissleder in Der Radiologe (2001)

Article

Bildgebung von Angiogenese

C. Bremer, A.A. Bogdanov, R. Weissleder in Der Radiologe (2001)

Article

Quantitation of HSV mass distribution in a rodent brain tumor model

A number of different viral vectors have been used for gene therapy of tumors, with many more under construction, ultimately designed to improve tumor targeting and transduction efficiency. It has become appar...

D Schellingerhout, N G Rainov, X O Breakefield, R Weissleder in Gene Therapy (2000)

Article

Application of a stable cell culture assay for the functional assessment of novel MR contrast agents

The purpose of this study was to apply a new cell culture assay that preserves hepatocyte orientation and differentiation for screening of MR contrast agents with hepatocyte specificity. Cultured hepatocytes ...

P. Reimer, A. Bader, R. Weissleder in European Radiology (1997)

Article

Entwicklung und experimenteller Einsatz von rezeptorspezifischen MR-Kontrastmitteln

In der vorliegenden Arbeit wird die Entwicklung und präklinische Erprobung rezeptorspezifischer MRT-Kontrastmittel zum verbesserten Nachweis pathologischer Prozesse und der Funktionsbeurteilung am Beispiel der...

P. Reimer, R. Weissleder in Der Radiologe (1996)

Article

Superparamegnetic iron oxides for MRI

Pharmaceutical iron oxide preparations have been used as MRI contrast agents for a variety of purposes. These agents predominantly decrease T2 relaxation times and therefore cause a decrease in signal intensit...

R. Weissleder, P. Reimer in European Radiology (1993)

Chapter and Conference Paper

MR Receptor Imaging of the Liver

Superparamagnetic iron oxides can be directed to specific organs and tissues for MR imaging by strategies such as receptor targeting. Targeting iron oxides to hepatocyte receptors rather then to liver macropha...

P. Reimer, R. Weissleder, A. S. Lee… in Computer Assisted Radiology / Computergest… (1991)

Chapter and Conference Paper

Leber- und Milzuntersuchungen mit superparamagnetischem Eisenoxid

Die Entwicklung von MR-Kontrastmitteln erfolgte, um den Bildkontrast zu verbessern und somit auch kleinere Läsionen zu erkennen, um die MR-Untersuchung zu vereinfachen, um den Patientendurchsatz zu erhöhen und...

R. Weissleder in Kernspintomographie der Abdominal- und Beckenorgane (1990)