Leber- und Milzuntersuchungen mit superparamagnetischem Eisenoxid

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Kernspintomographie der Abdominal- und Beckenorgane
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Zusammenfassung

Die Entwicklung von MR-Kontrastmitteln erfolgte, um den Bildkontrast zu verbessern und somit auch kleinere Läsionen zu erkennen, um die MR-Untersuchung zu vereinfachen, um den Patientendurchsatz zu erhöhen und um die Kosten zu reduzieren. Die Einführung der MR-Kontrastmittel hat gezeigt, daß trotz des bereits nativ ausgezeichneten Weichteilkontrastes der MR-Bilder die diagnostische Aussage der Kernspintomographie weiter verbessert werden kann.

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Literatur

  1. Bacic G, Niesman, M, Magin R, et al. (1987) The use of dextran-magnetite for liver enhancement. 328

    Google Scholar 

  2. Bassett M, Halliday J, Powell L (1986) Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology 6: 24–29

    Article  PubMed  CAS  Google Scholar 

  3. Brasch R, Bennet H (1988) Considerations in the choice of contrast media in MR imaging. Radiology 166: 897–899

    PubMed  CAS  Google Scholar 

  4. Elizondo G, Weissleder R, Hahn P, et al. (1989) Hepatic cirrhosis: Value of MR imaging using superparamagnetic iron oxide. Radiology. Im Druck

    Google Scholar 

  5. Fretz C, Elizondo G, Weissleder R, et al. (1989) Superparamagnetic iron oxide enhanced MR imaging: Pulse sequence optimization for detection of liver cancer. Radiology 172: 393–397

    Google Scholar 

  6. Fretz C, Stark D, Metz C, et al. (1989) Superparamagnetic iron oxide enhanced MR imaging of focal hepatic lesions: Controlled comparison with contrast-enhanced CT and non-contrast MR imanging. AJR. Im Druck.

    Google Scholar 

  7. Groman E, Josephson L, Lewis J (1989) Biologically degradable superparamagnetic materials for use in clinical applications. United States Patent 4, 827, 945.

    Google Scholar 

  8. Hemmingson A, Carlsten J, Ericsson A, et al. (1987) Relaxation enhancement of the dog liver and spleen by biodegradable superparamagnetic particles in proton magnetic resonance imaging. Acta Radiol. 28: 703–705.

    Article  Google Scholar 

  9. Hershko C, Cook J, Finch C (1973) Storage iron kinetics. III. Study of desferroxamine action by selective radioiron labels of RE and parenchymal cells. J Lab Clin Med 81: 876–886

    Google Scholar 

  10. Josephson L, Lewis J, Jacobs P, et al. (1988) The effects of iron oxides on proton relaxivity. Magn Reson Imaging 6: 647–653.

    Article  PubMed  CAS  Google Scholar 

  11. Marchal G, Van Hecke P, Demaerel P, et al. (1989) Detection of liver metastases with superparamagnetic iron oxide in 15 patients: Results of MR imaging at 1.5 T. AJR 152: 771–775

    PubMed  CAS  Google Scholar 

  12. Molday R, Mackenzie D (1982) Immunospecific ferromagnetic iron-dextran reagents for the labelling and magnetic separation of cells. J Immun Meth 52: 353–367

    Article  CAS  Google Scholar 

  13. Ohgushi M, Nagayama K, Wada A (1978) Dextran magnetite: a new relaxation agent and its application to T2 measurements in gel systms. J Mag Res 29: 599–601

    Article  CAS  Google Scholar 

  14. Olsson M, Persson B, Salford L, et al. (1986) Ferromagnetic particles as contrast agents in T2 NMR imaging. Mag Reson Imaging 4: 437–440

    Article  Google Scholar 

  15. Renshaw O, Owens C, McLaughlin A, et al. (1986) Ferromagnetic contrast agents: a new approach. Mag Reson Med 3: 217–255

    Article  CAS  Google Scholar 

  16. Stark D, Weissleder R, Elizondo G, et al. (1988) Superparamegnetic iron oxide: Clinical application as a contrast agent for MR imaging of the liver. Radiology 168: 297–301

    PubMed  CAS  Google Scholar 

  17. Weir M, Gibson J, Peters T (1984) Haemosiderosis and tissue damage. Cell Biochem Funct 2: 186–194

    Article  PubMed  CAS  Google Scholar 

  18. Weissleder R, Hahn P, Stark D, et al. (1987) MRI of the spleen: Ferrite enhanced detection of splenic metastases. AJR 149: 723–726

    PubMed  CAS  Google Scholar 

  19. Weissleder R, Stark D, Compton C, et al. (1987) MRI of hepatic lymphoma: An experimental study in rodents using ferrite. AJR 149: 1161–1165

    Google Scholar 

  20. Weissleder R, Saini S, Stark D, et al. (1988) Dual contrast MR Imaging: Animal investigation. AJR 150: 561–566

    PubMed  CAS  Google Scholar 

  21. Weissleder R, Stark D, Rummeny E, et al. (1988) Splenic lymphoma: Ferrite enhanced MR imaging in rats. Radiology 166: 423–430

    PubMed  CAS  Google Scholar 

  22. Weissleder R, Hahn P, Stark D, et al. (1988) Superparamagnetic iron oxide: Enhanced detection of focal splenic tumors with MR imaging. Radiology 169: 399–403

    PubMed  CAS  Google Scholar 

  23. Weissleder R, Stark D, Engelstad B, et al. (1989) Superparamagnetic iron oxide: Pharmacokinetics and toxicity. AJR 152: 167–173

    PubMed  CAS  Google Scholar 

  24. Weissleder R, Elizondo G, Stark D, et al. (1989) The diagnosis of splenic lymphoma by MR imaging: Value of superparamagnetic iron oxide. AJR 152: 175–180

    PubMed  CAS  Google Scholar 

  25. Widder D, Greif W, Widder K, et al. (1987) Magnetite albumin microspheres: a new MR contrast material. AJR 148: 399–404

    PubMed  CAS  Google Scholar 

  26. Wolf G, Burnett K, Goldstein E, et al. (1985) Contrast agents for magnetic resonance imaging. In: Kressel H (Hrsg.) Magnetic Resonance Annual. Raven, New York 241–265

    Google Scholar 

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© 1990 Springer-Verlag Berlin Heidelberg

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Weissleder, R. (1990). Leber- und Milzuntersuchungen mit superparamagnetischem Eisenoxid. In: Steinbrich, W., Krestin, G.P. (eds) Kernspintomographie der Abdominal- und Beckenorgane. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93460-5_4

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  • DOI: https://doi.org/10.1007/978-3-642-93460-5_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-93461-2

  • Online ISBN: 978-3-642-93460-5

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