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  1. Article

    Open Access

    Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau

    Tau protein hyperphosphorylation and aggregation are key pathological events in neurodegenerative tauopathies such as Alzheimer’s disease. Interestingly, seasonal hibernators show extensive tau hyperphosphoryl...

    C. F. de Veij Mestdagh, M. E. Witte, W. Scheper… in Acta Neuropathologica Communications (2024)

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  2. Article

    Open Access

    Plasma proteomic characterization of the development of acute kidney injury in early sepsis patients

    Acute kidney injury (AKI) develops frequently in the course of patients with sepsis and strongly associates with in-hospital mortality. However, diagnosing AKI involves a considerable lag-time because it depen...

    B. S. Star, C. K. Boahen, E. C. van der Slikke, V. M. Quinten… in Scientific Reports (2022)

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  3. Article

    Open Access

    The (R)-enantiomer of the 6-chromanol derivate SUL-121 improves renal graft perfusion via antagonism of the α1-adrenoceptor

    SUL-compounds are protectants from cold-induced ischemia and mitochondrial dysfunction. We discovered that adding SUL-121 to renal grafts during warm machine reperfusion elicits a rapid improvement in perfusio...

    D. Nakladal, H. Buikema, A. Reyes Romero, S. P. H. Lambooy, J. Bouma… in Scientific Reports (2019)

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  4. No Access

    Living Reference Work Entry In depth

    Hibernation and Torpor: Prospects for Human Spaceflight

    Despite substantial technical progress in the last decades, long-distance human space travel beyond the Earth-Moon system still represents a challenge. Resources for sustaining humans in good physical and ment...

    G. Petit, D. Koller, L. Summerer… in Handbook of Life Support Systems for Space…

  5. Article

    Open Access

    The Novel Compound Sul-121 Preserves Endothelial Function and Inhibits Progression of Kidney Damage in Type 2 Diabetes Mellitus in Mice

    Diabetic nephropathy is still a common complication of type 2 diabetes mellitus (T2DM) and improvement of endothelial dysfunction (ED) and inhibition of reactive oxygen species (ROS) are considered important t...

    S. P. H. Lambooy, A. Bidadkosh, D. Nakladal, A. van Buiten… in Scientific Reports (2017)

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  6. Article

    Erratum: Local gene therapy with indoleamine 2,3-dioxygenase protects against development of transplant vasculopathy in chronic kidney transplant dysfunction

    Correction to: Gene Therapy advance online publication 4 August 2016; doi:10.1038/gt.2016.59 Following the online publication of this article, noted that the article title contained errors. The complete and co...

    D Vavrincova-Yaghi, L E Deelman, H van Goor, M A Seelen, P Vavrinec… in Gene Therapy (2016)

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  7. No Access

    Article

    Local gene therapy with indoleamine 2,3-dioxygenase protects against development of transplant vasculopathy in chronic kidney transplant dysfunction

    Chronic transplant dysfunction (CTD) is the primary cause of late allograft loss in kidney transplantation. Indoleamine 2,3-dioxygenase (IDO) is involved in fetomaternal tolerance and IDO gene therapy inhibits...

    D Vavrincova-Yaghi, L E Deelman, H van Goor, M A Seelen, P Vavrinec… in Gene Therapy (2016)

  8. No Access

    Article

    Renal failure induces telomere shortening in the rat heart

    BackgroundRenal failure aggravates pathological cardiac remodelling induced by myocardial infarction (MI). Cardiac remodelling is associated with telomere shortening, a marker for biological ageing. We investigat...

    L. S. Wong, W. A. Windt, A. J. Roks, R. P. van Dokkum… in Netherlands Heart Journal (2009)

  9. No Access

    Article

    Ultrasound and microbubble-targeted delivery of therapeutic compounds

    The molecular understanding of diseases has been accelerated in recent years, producing many new potential therapeutic targets. A noninvasive delivery system that can target specific anatomical sites would be ...

    L. J. M. Juffermans, A. van Wamel, R. H. Henning, K. Kooiman… in Netherlands Heart Journal (2009)

  10. No Access

    Article

    Rescue of arterial function by angiotensin-(1-7): towards improvement of endothelial function by drug-eluting stents

    Purpose: To explore the hypothesis that stent placement decreases dilator function of various arteries outside the stented segment and that angiotensin- (1-7) improves this function, and to assess the contributio...

    B. E. Langeveld, R. H. Henning, B. J. G. L. de Smet… in Netherlands Heart Journal (2008)

  11. No Access

    Article

    Cardiac overexpression of human VEGF165 by recombinant Semliki Forest virus leads to adverse effects in pressure-induced heart failure

    Semliki Forest virus (SFV) is an efficient vector for cardiac gene delivery. The relatively short transgene expression induced by SFV seems appropriate for angiogenic gene therapy. We tested the effects of SFV...

    A. E. Loot, A. J. M. Roks, D. Westermann, H-D. Orzechowski… in Netherlands Heart Journal (2007)

  12. No Access

    Article

    Recombinant Semliki Forest virus as a vector system for fast and selective in vivo gene delivery into balloon-injured rat aorta

    Previously, we demonstrated that recombinant Semliki Forest virus (SFV) vector rapidly and selectively transfers genes into cultured vascular smooth muscle cells (VSMC), leaving endothelial cells (EC) unaffect...

    A J M Roks, R H Henning, H Buikema, Y M Pinto, M J J Kraak, R A Tio… in Gene Therapy (2002)

  13. No Access

    Chapter

    Molecular Mechanisms of Remodeling in Human Atrial Fibrillation

    Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Most frequently, AF occurs in conjunction with other cardiovascular disease, such as hypertension, ischemic heart disease, va...

    B. J. J. M. Brundel, R. H. Henning… in Cardiovascular Genomics: New Pathophysiolo… (2002)

  14. No Access

    Article

    Opening up Ca2+ stores with lnsP3

    L. Missiaen, J. B. Parys, H. De Smedt, I. Sienaert, R. H. Henning, R. Casteels in Nature (1995)

  15. No Access

    Chapter and Conference Paper

    Female Rats are More Sensitive to the Neuromuscular Blocking Action of Rocuronium than Male Rats

    Potency (1), being the result of pharmacokinetics and pharmacodynamics, and sensitivity (intrinsic potency) (2), which is based solely on pharmacodynamics, have been reported to differ for NMBAs between male a...

    E. Maestrone, R. H. Henning, M. C. Houwertjes, J. M. K. H. Wierda in Muscle Relaxants (1995)

  16. No Access

    Chapter and Conference Paper

    Regulation of Innervation-Related Properties of Cultured Skeletal Muscle Cells by Transmitter and Co-Transmitters

    Long-term interruption of the neuromuscular transmission induces marked changes in properties of skeletal muscle cells. These reversible changes were recognized for the first time in surgically denervated musc...

    R. H. Henning in Muscle Relaxants (1995)

  17. No Access

    Article

    Abstracts of papers and posters

    R. L. Anthonio, A. T. M. Willemsen, T. Visser, A. van Waarde… in Pharmacy World and Science (1994)