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  1. No Access

    Article

    Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

    A restricted diet extends the lives and improves the health of mice with accelerated ageing due to an inability to repair DNA damage.

    W. P. Vermeij, M. E. T. Dollé, E. Reiling, D. Jaarsma, C. Payan-Gomez… in Nature (2016)

  2. No Access

    Article

    Regenerative cell therapy and pharmacotherapeutic intervention in heart failure

    Regenerative medicine represents a promising perspective on therapeutic angiogenesis in patients with cardiovascular disease, including heart failure. However, previous or ongoing clinical trials show ambiguou...

    C. Qian, R. G. Schoemaker, W. H. van Gilst, B. Yu… in Netherlands Heart Journal (2008)

  3. No Access

    Article

    Rescue of arterial function by angiotensin-(1-7): towards improvement of endothelial function by drug-eluting stents

    Purpose: To explore the hypothesis that stent placement decreases dilator function of various arteries outside the stented segment and that angiotensin- (1-7) improves this function, and to assess the contributio...

    B. E. Langeveld, R. H. Henning, B. J. G. L. de Smet… in Netherlands Heart Journal (2008)

  4. No Access

    Article

    Regenerative cell therapy and pharmacotherapeutic intervention in heart failure

    It has been postulated that bone marrow derived endothelial progenitor cells (BM-EPCs) are essential for neovascularisation and endothelial repair and are involved in pharmacological treatment, and even its po...

    C. Qian, R. G. Schoemaker, W. H. van Gilst, B. Yu… in Netherlands Heart Journal (2008)

  5. No Access

    Article

    Cardiac overexpression of human VEGF165 by recombinant Semliki Forest virus leads to adverse effects in pressure-induced heart failure

    Semliki Forest virus (SFV) is an efficient vector for cardiac gene delivery. The relatively short transgene expression induced by SFV seems appropriate for angiogenic gene therapy. We tested the effects of SFV...

    A. E. Loot, A. J. M. Roks, D. Westermann, H-D. Orzechowski… in Netherlands Heart Journal (2007)

  6. No Access

    Article

    Recombinant Semliki Forest virus as a vector system for fast and selective in vivo gene delivery into balloon-injured rat aorta

    Previously, we demonstrated that recombinant Semliki Forest virus (SFV) vector rapidly and selectively transfers genes into cultured vascular smooth muscle cells (VSMC), leaving endothelial cells (EC) unaffect...

    A J M Roks, R H Henning, H Buikema, Y M Pinto, M J J Kraak, R A Tio… in Gene Therapy (2002)