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Article
Open AccessThe BDNF Val66Met polymorphism regulates glucocorticoid-induced corticohippocampal remodeling and behavioral despair
The BDNF Val66Met polymorphism has been associated with sensitivity to stress and affective disorders. We therefore sought to model the inter-causality of these relationships under controlled laboratory condit...
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Article
The Potential of Gonadal Hormone Signalling Pathways as Therapeutics for Dementia
Dementia is an ever-expanding problem facing an ageing society. Currently, there is a sharp paucity of treatment strategies. It has long been known that sex hormones, namely 17β-estradiol and testosterone, pos...
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Article
Open AccessAnalyzing the influence of BDNF heterozygosity on spatial memory response to 17β-estradiol
The recent use of estrogen-based therapies as adjunctive treatments for the cognitive impairments of schizophrenia has produced promising results; however the mechanism behind estrogen-based cognitive enhancem...
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Article
Change in Nox4 expression is accompanied by changes in myogenic marker expression in differentiating C2C12 myoblasts
Myoblast differentiation is mediated by a cascade of changes in gene expression including transcription factors such as myogenin. Subsequent to myoblast differentiation, there is an increase in expression of t...