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Article
Non-coding RNAs regulating mitochondrial function in cardiovascular diseases
Cardiovascular disease (CVD) is the leading cause of disease-related death worldwide and a significant obstacle to improving patients’ health and lives. Mitochondria are core organelles for the maintenance of ...
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Article
Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury
Acetaminophen (APAP) overdose is a common cause of drug-induced liver injury (DILI). Ferroptosis has been recently implicated in APAP-induced liver injury (AILI). However, the functional role and underlying me...
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Article
Open AccessAnalysis of clinical characteristics and genetic testing in patients with acute fatty liver of pregnancy: a retrospective study
Acute fatty liver of pregnancy (AFLP) is an acute, rare and potentially lethal disease typically occurring in the third trimester of pregnancy. So far, there is no effective means of prevention. Therefore, in ...
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Article
GADD45α alleviates acetaminophen-induced hepatotoxicity by promoting AMPK activation
As an analgesic and antipyretic drug, acetaminophen (APAP) is commonly used and known to be safe at therapeutic doses. In many countries, the overuse of APAP provokes acute liver injury and even liver failure....
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Article
A conjugated polymer-Gd (III) complex as pH sensitive contrast agent in magnetic resonance imaging
A novel pH-responsive contrast agent (PFP-aa/Gd) for magnetic resonance imaging (MRI) was prepared by binding Gd(III) to a water-soluble conjugated polyfluorene with pendant carboxylate and amine moieties. The...
