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Article
Open AccessCommonly used software tools produce conflicting and overly-optimistic AUPRC values
The precision-recall curve (PRC) and the area under the precision-recall curve (AUPRC) are useful for quantifying classification performance. They are commonly used in situations with imbalanced classes, such ...
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Chapter and Conference Paper
Research on Multi-objective Intelligent Optimization of Vehicle Body Platform Performance
The purpose of this paper is to study the platform performance optimization method based on implicit parametric body. Firstly, the body structure path is optimized based on topology optimization; Secondly, an ...
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Article
Open AccessSerine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM
Bacteria develop a variety of extracellular fibrous structures crucial for their survival, such as flagella and pili. In this study, we use cryo-EM to identify protein fibrils surrounding lab-cultured Bacillus am...
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Article
Quantitative calculation of gases generation during low-temperature oxidation of coal
The gases evolution during the low-temperature oxidation of coal is an essential parameter used to assess the state of coal oxidation and to estimate the gaseous pollutants. However, the current semi-quantitat...
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Article
Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43
Frontotemporal lobar degeneration (FTLD) is the third most common neurodegenerative condition after Alzheimer’s and Parkinson’s diseases1. FTLD typically presents in 45 to 64 year olds with behavioural changes or...
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Article
Reusability report: Capturing properties of biological objects and their relationships using graph neural networks
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Article
Open AccessCorrection to: Metabolic analysis of early nonalcoholic fatty liver disease in humans using liquid chromatography–mass spectrometry
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Article
Open AccessThe hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein
α-Synuclein (α-Syn) can form different fibril strains with distinct polymorphs and neuropathologies, which is associated with the clinicopathological variability in synucleinopathies. How different α-syn fibri...
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Article
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Amyloidosis of human islet amyloid polypeptide (hIAPP) is a pathological hallmark of type II diabetes (T2D), an epidemic afflicting nearly 10% of the world’s population. To visualize disease-relevant hIAPP fib...
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Article
Open AccessLight-fueled transient supramolecular assemblies in water as fluorescence modulators
Dissipative self-assembly, which requires a continuous supply of fuel to maintain the assembled states far from equilibrium, is the foundation of biological systems. Among a variety of fuels, light, the origin...
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Article
Refolding Behavior of Urea-Induced Denaturation Collagen
Exploration of the denaturation and refolding of natural collagen is important for the application of collagen and its denatured products. In this study, using urea as a denaturant, we prepared a denatured nat...
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Article
Open AccessCorrection to: Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessMetabolic analysis of early nonalcoholic fatty liver disease in humans using liquid chromatography-mass spectrometry
Nonalcoholic fatty liver disease (NAFLD) is a common metabolic disease that affects 20–30% of individuals worldwide. Liver puncture remains the gold standard for the diagnosis of liver diseases despite limitat...
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Article
Open AccessSocial hierarchy and the choice of metal recycling at Anyang, the last capital of Bronze Age Shang China
Anyang, the last capital of the Chinese Shang dynasty, became one of the largest metal consumers in Eurasia during the second millennium BCE. However, it remains unclear how Anyang people managed to sustain su...
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Article
Open AccessChiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease
Preventing aggregation of amyloid beta (Aβ) peptides is a promising strategy for the treatment of Alzheimer’s disease (AD), and gold nanoparticles have previously been explored as a potential anti-Aβ therapeut...
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Article
Open AccessCryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid
hnRNPA2 is a human ribonucleoprotein (RNP) involved in RNA metabolism. It forms fibrils both under cellular stress and in mutated form in neurodegenerative conditions. Previous work established that the C-term...
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Article
A unified framework for integrative study of heterogeneous gene regulatory mechanisms
Gene expression is regulated by a large variety of mechanisms. Previous studies attempting to model the quantitative relationships between gene expression levels and regulatory mechanisms have considered only ...
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Article
Open AccessAn integrative ENCODE resource for cancer genomics
ENCODE comprises thousands of functional genomics datasets, and the encyclopedia covers hundreds of cell types, providing a universal annotation for genome interpretation. However, for particular applications,...
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Article
Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils
Human islet amyloid polypeptide (hIAPP) functions as a glucose-regulating hormone but deposits as amyloid fibrils in more than 90% of patients with type II diabetes (T2D). Here we report the cryo-EM structure ...
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Article
Comprehensive Analysis of Serum and Fecal Bile Acid Profiles and Interaction with Gut Microbiota in Primary Biliary Cholangitis
Accumulation of bile acids (BAs) contributes significantly to the pathogenesis of primary biliary cholangitis (PBC). Here, we sought to systematically characterize the serum and fecal BA profiles and the linka...
