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Article
Open AccessAccelerating the transition to cobalt-free batteries: a hybrid model for LiFePO4/graphite chemistry
The increased adoption of lithium-iron-phosphate batteries, in response to the need to reduce the battery manufacturing process’s dependence on scarce minerals and create a resilient and ethical supply chain, ...
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Article
Applications of artificial intelligence−machine learning for detection of stress: a critical overview
Psychological distress is a major contributor to human physiology and pathophysiology, and it has been linked to several conditions, such as auto-immune diseases, metabolic syndrome, sleep disorders, and suici...
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Article
Open AccessAuthor Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
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Article
Open AccessSTARRPeaker: uniform processing and accurate identification of STARR-seq active regions
STARR-seq technology has employed progressively more complex genomic libraries and increased sequencing depths. An issue with the increased complexity and depth is that the coverage in STARR-seq experiments is...
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Article
Open AccessNIMBus: a negative binomial regression based Integrative Method for mutation Burden Analysis
Identifying frequently mutated regions is a key approach to discover DNA elements influencing cancer progression. However, it is challenging to identify these burdened regions due to mutation rate heterogeneit...
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Article
Improvement with the Multi-material Decomposition Framework in Dual-energy Computed Tomography: A Phantom Study
Dual energy computed tomography (DECT) enhances tissue characterization by obtaining two or three material images from two measurements with different X-ray spectra. Recently, multi-material decomposition (MMD...
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Article
Open AccessRADAR: annotation and prioritization of variants in the post-transcriptional regulome of RNA-binding proteins
RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation and disease. Their binding sites cover more of the genome than coding exons; nevertheless, most noncoding variant prioritization me...
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Article
Open AccessAn integrative ENCODE resource for cancer genomics
ENCODE comprises thousands of functional genomics datasets, and the encyclopedia covers hundreds of cell types, providing a universal annotation for genome interpretation. However, for particular applications,...
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Article
Open AccessDiNeR: a Differential graphical model for analysis of co-regulation Network Rewiring
During transcription, numerous transcription factors (TFs) bind to targets in a highly coordinated manner to control the gene expression. Alterations in groups of TF-binding profiles (i.e. “co-binding changes”...
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Article
Investigation of Human and Model Observer Performance of Mass Detection in a Prototype Digital Breast Tomosynthesis System
Task-based assessment of image quality using a theoretical observer model has recently gained attention in medical imaging fields. Observer models whose performance can suitably match that of a human observer ...
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Article
Open AccessAnalyses of non-coding somatic drivers in 2,658 cancer whole genomes
The discovery of drivers of cancer has traditionally focused on protein-coding genes1–4. Here we present analyses of driver point mutations and structural variants in non-coding regions across 2,658 genomes from ...
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Article
Integrating climate prediction and regionalization into an agro-economic model to guide agricultural planning
Advanced skill in seasonal climate prediction coupled with sectoral decision models can provide decision makers with opportunities to benefit or reduce unnecessary losses. Such approaches are particularly bene...
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Chapter and Conference Paper
Longitudinal Prediction of Radiation-Induced Anatomical Changes of Parotid Glands During Radiotherapy Using Deep Learning
During a course of radiotherapy, patients may have weight loss and radiation induced anatomical changes. To avoid delivering harmful dose to normal organs, the treatment may need adaptation according to the ch...
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Article
Cost-effectiveness of smoking cessation programs for hospitalized patients: a systematic review
This systematic review examined the characteristics of published cost-effectiveness analyses of inpatient smoking cessation programs and assessed the methodological quality of the selected studies, to provide ...
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Article
Restoration of Full Data from Sparse Data in Low-Dose Chest Digital Tomosynthesis Using Deep Convolutional Neural Networks
Chest digital tomosynthesis (CDT) provides more limited image information required for diagnosis when compared to computed tomography. Moreover, the radiation dose received by patients is higher in CDT than in...
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Article
MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis
Vertebrate tissues exhibit mechanical homeostasis, showing stable stiffness and tension over time and recovery after changes in mechanical stress. However, the regulatory pathways that mediate these effects ar...
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Chapter and Conference Paper
Vehicle Communication Using Secrecy Capacity
We address secure vehicle communication using secrecy capacity. In particular, we research the relationship between secrecy capacity and various types of parameters that determine secrecy capacity in the vehi...
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Article
Open AccessEvaluation of pancreatic tumor development in KPC mice using multi-parametric MRI
Pancreatic ductal adenocarcinoma (PDA) is a fatal disease with very poor prognosis. Development of sensitive and noninvasive methods to monitor tumor progression in PDA is a critical and unmet need. Magnetic r...
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Article
Open AccessStructural Insight into Substrate Specificity of 3-Hydroxypropionyl-Coenzyme A Dehydratase from Metallosphaera sedula
Metallosphaera sedula is a thermoacidophilic autotrophic archaeon known to utilize the 3-hydroxypropionate/4-hydroxybutyrate cycle (3-HP/4-HB cycle) as carbon fixation pathway. 3-Hydroxypropionyl-CoA dehydratase ...
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Article
Open AccessCost-effectiveness of antiviral prophylaxis during pregnancy for the prevention of perinatal hepatitis B infection in South Korea
In Korea, hepatitis B virus (HBV) infection accounts for approximately 65–75% of HBV-related diseases, such as chronic hepatitis and liver cancer, and mother-to-child transmission is presumed to be a major sou...
