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Article
Open AccessAuthor Correction: In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men
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Article
Open AccessIn vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men
The regional integrity of brain subcortical structures has been implicated in sleep–wake regulation, however, their associations with sleep parameters remain largely unexplored. Here, we assessed association b...
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Article
Open AccessLight modulates task-dependent thalamo-cortical connectivity during an auditory attentional task
Exposure to blue wavelength light stimulates alertness and performance by modulating a widespread set of task-dependent cortical and subcortical areas. How light affects the crosstalk between brain areas to tr...
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Article
Systematic Review of Different Neuroimaging Correlates in Mild Cognitive Impairment and Alzheimer’s Disease
Alzheimer’s disease (AD) is a heterogeneous progressive neurocognitive disorder. Although different neuroimaging modalities have been used for the identification of early diagnostic and prognostic factors of A...
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Article
Open AccessA systematic review and integrative approach to decode the common molecular link between levodopa response and Parkinson’s disease
PD is a progressive neurodegenerative disorder commonly treated by levodopa. The findings from genetic studies on adverse effects (ADRs) and levodopa efficacy are mostly inconclusive. Here, we aim to identify ...
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Emerging Themes in Drug Resistance
In the last century, advances in biomedical sciences led to improvements in quality of human life mainly by decreasing the disease burden and providing various healthcare innovations. Effective medications wer...
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Article
Dissecting Complex and Multifactorial Nature of Alzheimer’s Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by loss of memory and other cognitive functions. AD can be classified into familial AD (FAD) and sporadic AD (SAD) based on he...
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Chapter
Systems Pharmacology and Pharmacogenomics for Drug Discovery and Development
Systems pharmacology involves the application of systems biology approaches, integrating high throughput experimental data from different experimental techniques such as genomics and proteomics involving compu...
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Article
Open AccessGenomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease
Alzheimer’s disease (AD) is one of the leading genetically complex and heterogeneous disorder that is influenced by both genetic and environmental factors. The underlying risk factors remain largely unclear fo...
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Article
S-linked protein homocysteinylation: identifying targets based on structural, physicochemical and protein–protein interactions of homocysteinylated proteins
An elevated level of homocysteine, a thiol-containing amino acid is associated with a wide spectrum of disease conditions. A majority (>80 %) of the circulating homocysteine exist in protein-bound form. Homocy...
