Breast Cancer Radiation Therapy
A Practical Guide for Technical Applications
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Open AccessA BRILLIANT-BRCA study: residual breast tissue after mastectomy and reconstruction
Different types of mastectomies leave different amounts of residual breast tissue. The significance of the residual breast volume (RBV) is not clear. Therefore, we developed an MRI tool that allows to easily a...
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Joint EANM-SNMMI guidelines on the role of 2-[18F]FDG PET/CT in no special type breast cancer: differences and agreements with European and American guidelines
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Open AccessJoint EANM-SNMMI guideline on the role of 2-[18F]FDG PET/CT in no special type breast cancer
There is much literature about the role of 2-[18F]FDG PET/CT in patients with breast cancer (BC). However, there exists no international guideline with involvement of the nuclear medicine societies about this sub...
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Optimising of axillary therapy in breast cancer: lessons from the past to plan for a better future
In this narrative review, we aim to explore the ability of radiation therapy to eradicate breast cancer regional node metastasis. It is a journey through data of older trials without systemic therapy showing t...
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Tumour Bed Boost Radiotherapy and Planning Following Partial Breast Reconstruction with Chest Wall Perforator Flaps
The addition of a tumour bed boost to whole breast irradiation reduces the risk of local recurrence, especially in younger patients with high-risk tumours. The use of tumour bed boost in volume replacement onc...
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Open AccessThe Italian Association for Radiotherapy and Clinical Oncology (AIRO) position statements for postoperative breast cancer radiation therapy volume, dose, and fractionation
Recent advances in non-metastatic breast cancer radiation therapy significantly reshaped our views on modern dose and fractionation schedules. Especially the advent of hypofractionation and partial breast irra...
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Management and Workflow
Radiation therapy (RT) is an important modality of breast cancer patients, regardless of disease stage. In breast cancer, in addition to curative indications, RT is a major modality for palliation or symptom c...
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Non-resectable Patients
The term non-resectable (inoperable) breast cancer refers to the situation where upfront surgery will not achieve complete excision of all tumours with clear margins. These cancers can present as primary local...
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Available Infrastructure
Radiation therapy, being an integral part of the treatment of most non-metastatic breast cancer patients and contributing to the management in the metastatic setting (e.g. pain and other symptoms relief, palli...
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Target Volume Definition and Delineation Boost/PBI/SIB
An additional radiation dose (boost) to the primary tumour bed is indicated in case of high-risk breast cancer, while partial breast irradiation (PBI) can be used for low-risk breast cancer patients. For both ...
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Treatment Planning for Challenging Anatomies
Treatment planning procedures are set up to obtain optimised dose distributions for the “average” patient. Whereas with individualisation of treatment planning a good compromise between dose objectives for the...
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Follow-Up During Treatment
In the following section we discuss the rationale for a follow-up schedule for breast cancer patients during a radiation course, with regard to various treatment protocols.
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General Management
Substantial progress has been made in the conceptual approach and clinical management of breast cancer over the past decades. Over the last years, radiation oncology focussed a lot on the challenges related to...
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Open AccessNeo-CheckRay: radiation therapy and adenosine pathway blockade to increase benefit of immuno-chemotherapy in early stage luminal B breast cancer, a randomized phase II trial
Residual breast cancer after neo-adjuvant chemotherapy (NACT) predicts disease outcome and is a surrogate for survival in aggressive breast cancer (BC) subtypes. Pathological complete response (pCR) rate, howe...
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Spatial location of local recurrences after mastectomy: a systematic review
We performed a systematic review to document the spatial location of local recurrences (LR) after mastectomy.
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T-Staging and Target Volume Definition by Imaging in Breast Tumours
Breast cancer is the most frequent cancer in women in both developed and develo** countries. Early detection of breast cancer is of great importance, as it allows carrying out less mutilating or aggressive t...
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Open AccessType of preoperative therapy and stage-specific survival after surgery for rectal cancer: a nationwide population-based cohort study
Preoperative chemoradiation therapy (CRT) may induce downstaging in rectal cancer (RC). Short-course radiation therapy (SC-RT) with immediate surgery does not cause substantial downstaging. However, the TNM cl...
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When Can We Avoid Postmastectomy Radiation Following Primary Systemic Therapy?
Postmastectomy radiation therapy (PMRT) has been shown to reduce the risk of locoregional recurrences (LRR) and of distant metastases (DM) and to improve breast cancer–specific survival (BCSS) as well as overa...
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Breast cancer
Breast cancer is the most frequent malignancy in women worldwide and is curable in ~70–80% of patients with early-stage, non-metastatic disease. Advanced breast cancer with distant organ metastases is consider...
