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Article
Open AccessAntibodies toward Na+,HCO3–-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer
Na+,HCO3–-cotransporter NBCn1/Slc4a7 accelerates murine breast carcinogenesis. Lack of specific pharmacological tools previously restricted therapeutic targeting of NBCn1 and identification of NBCn1-dependent fun...
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Article
Open AccessIncreased lesion detectability in patients with locally advanced breast cancer—A pilot study using dynamic whole-body [18F]FDG PET/CT
Accurate diagnosis of axillary lymph node (ALN) metastases is essential for prognosis and treatment planning in breast cancer. Evaluation of ALN is done by ultrasound, which is limited by inter-operator variab...
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Article
Open AccessDynamic whole-body [18F]FES PET/CT increases lesion visibility in patients with metastatic breast cancer
Correct classification of estrogen receptor (ER) status is essential for prognosis and treatment planning in patients with breast cancer (BC). Therefore, it is recommended to sample tumor tissue from an access...
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Article
Optimising of axillary therapy in breast cancer: lessons from the past to plan for a better future
In this narrative review, we aim to explore the ability of radiation therapy to eradicate breast cancer regional node metastasis. It is a journey through data of older trials without systemic therapy showing t...
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Pathology Report
The pathology report should provide accurate diagnostic, prognostic and predictive information, including information about completeness of resection, according to timeliness required for tissue-processing wit...
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Article
Open AccessIntegrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome
Breast cancer is a heterogeneous disease at the clinical and molecular level. In this study we integrate classifications extracted from five different molecular levels in order to identify integrated subtypes.
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Article
Co-expression of p16 and p53 characterizes aggressive subtypes of ductal intraepithelial neoplasia
In the USA alone, approximately 61,000 new diagnoses of ductal intraepithelial neoplasia 1c-3 (DIN) are made each year. Around 10–20 % of the patients develop a recurrence, about 50 % of which are invasive. Pr...
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Article
Expression of C-KIT, CD24, CD44s, and COX2 in benign and non-invasive apocrine lesions of the breast
Benign apocrine metaplasia (AM) of the adult breast is a very common, but enigmatic lesion. It has been speculated that AM might be a precursor of malignancy or an indicator of a susceptibility of the breast t...
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Article
Reliable PCR quantitation of estrogen, progesterone and ERBB2 receptor mRNA from formalin-fixed, paraffin-embedded tissue is independent of prior macro-dissection
Gene expression analysis on messenger RNA (mRNA) purified from formalin-fixed, paraffin-embedded tissue is increasingly used for research purposes. Tissue heterogeneity may question specificity and interpretat...
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Article
Open AccessIndividual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors
The global effect of copy number and epigenetic alterations on miRNA expression in cancer is poorly understood. In the present study, we integrate genome-wide DNA methylation, copy number and miRNA expression ...
